Effect of particle morphology on emitted dose of fatty acid-treated disodium cromoglycate powder aerosols

Pharmaceutical Development and Technology
K A FultsAnthony J Hickey

Abstract

These studies assess the quantity and morphology of the emitted aerosolized dose of irregularly shaped disodium cromoglycate particles in the fine particle fraction using in vitro methods. Disodium cromoglycate was treated with a homologous series of saturated fatty acids, between C8 and C18, in a range of concentrations. The products of these treatments were powders with a variety of particle size, shape, and aggregation characteristics. Samples of these powders were loaded in gelatin capsules, generated as aerosols from a Rotahaler and collected in a two-stage liquid impinger or eight-stage inertial impactor. Particles were examined directly by scanning electron microscopy and subsequently the images were analyzed to define morphology. The aerodynamic fine-particle fraction determined by the two-stage impinger increased approximately twofold with lauric acid treatment (0.0317 g/g, 6.7%) and threefold with stearic acid treatment (0.58 g/g; 9.7%) compared with disodium cromoglycate alone (0 g/g, 3.56%). The lauric acid formulation appeared to alter deposition primarily by changing particle morphology. Stearic acid altered particle shape to some extent and the increase in the fine-particle fraction appeared to be attributable to...Continue Reading

References

Dec 1, 1974·The Journal of Pharmacy and Pharmacology·S H CurryE Zeidifard
Oct 1, 1971·Journal of Pharmaceutical Sciences·J S CoxW C McCrone
Jan 1, 1967·The Review of Scientific Instruments·B Y LiuH H Yu

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Citations

Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lucila Garcia-ContrerasDavid Edwards
Apr 6, 2012·The AAPS Journal·Wallace P AdamsAnthony J Hickey
Mar 9, 2011·International Journal of Nanomedicine·Hf SalemMa Sharaf
Apr 17, 2014·Advanced Drug Delivery Reviews·Anne Marie HealyLidia Tajber
Sep 2, 2005·Journal of Pharmaceutical Sciences·Nora Y K ChewHak-Kim Chan
Dec 18, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Deepak J SinghMala D Menon
May 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andreas WesselFrancis G Howarth
Dec 17, 2017·Journal of Pharmaceutical Sciences·Martin W JetzerGeorgios Imanidis

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