Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants.

AAPS PharmSciTech
Ahmad Almaya, Aktham Aburub

Abstract

This work investigates the effect of excipient particle size on compaction properties of brittle, plastic and viscoelastic materials with and without added lubricants. Sieve cuts of microcrystalline cellulose (MCC), starch and dibasic calcium phosphate dihydrate were obtained by sieving, then samples were tested without lubrication or with added lubricant (0.5% Mg stearate mixed for either 5 or 30-min). Compacts were left overnight before testing. It was found that in the absence of lubricant, compact tensile strength (TS) was dependent on particle size only for starch. With Mg stearate, lubricant sensitivity shows a strong dependence on excipient particle size for both starch and MCC, where smaller particles are less affected by lubricant. Dibasic calcium phosphate dihydrate was not sensitive to lubricant even after 30 min mixing. This study highlights that in the absence of lubricant, initial particle size of excipients has no impact on compact strength not only for dibasic calcium phosphate dihydrate (brittle), but also for MCC (plastic). On the other hand, TS is dependent on particle size both with or without added lubricant for starch (viscoelastic).

References

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Citations

Feb 7, 2012·Drug Development and Industrial Pharmacy·Patrick OkoyeRutesh H Dave
Jul 12, 2012·Drug Development and Industrial Pharmacy·Takehiko HorioShuji Matsusaka
Apr 13, 2012·Drug Development and Industrial Pharmacy·Marcos LlusáFernando J Muzzio
Jan 7, 2015·Journal of Pharmaceutical Sciences·Johanna Mosig, Peter Kleinebudde
Feb 24, 2016·International Journal of Pharmaceutics·B YohannesA M Cuitiño
Jul 30, 2010·International Journal of Pharmaceutics·Joseph Kushner, Francis Moore
May 30, 2015·AAPS PharmSciTech·Özgür KeleṣKeith J Bowman
Jul 6, 2014·International Journal of Pharmaceutics·Gregory ThoorensBrigitte Evrard
Dec 6, 2014·International Journal of Pharmaceutics·Margot FonteyneThomas De Beer
Jul 26, 2019·Pharmaceutical Development and Technology·Mariana BabayevaBilge A Selvi
Jan 5, 2018·Drug Development and Industrial Pharmacy·Biplob MitraSy-Juen Wu
Apr 8, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Afewerk GetachewSolomon Abrha
Dec 17, 2020·Pharmaceutical Development and Technology·João HenriquesSlavomíra Doktorovová
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis Eduardo Serrano-MoraDavid Quintanar-Guerrero
May 10, 2021·International Journal of Pharmaceutics·Natalia VeronicaPaul Wan Sia Heng
Aug 7, 2021·International Journal of Pharmaceutics·Cedrine de BackereValérie Vanhoorne

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