PMID: 9659608Jul 11, 1998Paper

Effect of particulate bioactive glass on human synoviocyte cultures

Journal of Biomedical Materials Research
S P BendallDavid S Hungerford

Abstract

Bioglass is a resorbable glass material that has been shown to induce osteoblast proliferation as well as bone matrix production in vitro. Its physico-chemical properties have been reported to be suitable for use as an implant coating for arthroplasty. However, Bioglass is a ceramic material that can fragment into particulate debris in vivo. The effect of particulate Bioglass on tissue cells has not been defined. In order to determine the biologic response to particulate Bioglass, we tested its effect on human synoviocytes in a cell culture model. At the concentrations of 1.0 and 10, micrograms/mL, particulate Bioglass (sizes ranging from approximately 0.5 to 80 microns) had a low cytotoxic effect. However, these concentrations induced secretion of TNF alpha. The observation that particulate Bioglass elicits release of inflammatory cytokines suggests that the development of this bioceramic implant coating should address techniques that would minimize the generation of particulates.

References

May 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A Collins, T J Chambers
Jan 1, 1992·The Journal of Bone and Joint Surgery. British Volume·N A AthanasouC J Bulstrode
May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S M HorowitzL Riley
Jun 1, 1989·Journal of Autoimmunity·F M BrennanM Feldmann
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S M HorowitzD W Lennox
Jul 1, 1987·Biomaterials·T Matsuda, J E Davies
Mar 1, 1971·Clinical Orthopaedics and Related Research·W T Green
Jan 1, 1973·Journal of Biomedical Materials Research·L L Hench, H A Paschall
Mar 1, 1995·Journal of Biomedical Materials Research·A el-GhannamI M Shapiro
Apr 1, 1995·Journal of Biomedical Materials Research·K KuboT Sueda
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M D LazarusD G Baker
Jan 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H GelbD G Baker
Mar 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P E GreisC H Evans
Apr 1, 1996·Journal of Biomedical Materials Research·O Peitl FilhoL L Hench
Nov 22, 1997·Journal of Biomedical Materials Research·N PriceD S Hungerford

❮ Previous
Next ❯

Citations

Dec 17, 2002·Journal of Biomedical Materials Research. Part a·Michela BosettiMario Cannas
Sep 3, 2008·Journal of Materials Science. Materials in Medicine·Sheng HuCongqin Ning
Nov 21, 2007·Journal of Biomedical Materials Research. Part a·Angela Y AuCarmelita G Frondoza
Feb 27, 2010·Journal of Biomedical Materials Research. Part a·Angela Y AuCarmelita G Frondoza
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Phong V PhanCarmelita G Frondoza
Feb 17, 2005·Journal of Biomedical Materials Research. Part a·Richard M Day, Aldo R Boccaccini
Aug 18, 2004·In Vitro Cellular & Developmental Biology. Animal·Carmelita G FrondozaLars Lindmark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.