PMID: 11604256Oct 18, 2001Paper

Effect of passive and iontophoretic skin pretreatments with terpenes on the in vitro skin transport of piroxicam

International Journal of Pharmaceutics
A DoliwaP Ygartua

Abstract

The enhancing effect of several terpenes (thymol, menthone and 1,8-cineole) in the percutaneous permeation of piroxicam (Px), either passive or iontophoretically, was investigated. These terpenes were applied, on the skin membrane, as a passive and iontophoretic skin pretreatment. Px was delivered from carbopol gels containing hydroxypropyl-beta-cyclodextrin (2% w/w Px). An increase in Px flux values, both passive and iontophoretic after skin pretreatment with 5% terpenes/50% EtOH, was found to be in the following order: thymol>menthone>1,8-cineole. Iontophoretic skin pretreatment with terpenes produced a slight increase in the passive flux of Px, in comparison with the passive skin pretreatment. This result indicated that iontophoresis could modify the skin morphology and consequently, increase the passive transport of Px. However, when Px was transported iontophoretically, passive skin pretreatment with terpenes, produced higher flux values than iontophoretic skin pretreatment. These results could be explained by the fact that with the iontophoretic pretreatment, terpenes could penetrate into the skin and limitate the movement of the ionized species, across the skin, during the iontophoretic experiments. The amount of Px reta...Continue Reading

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Citations

Mar 26, 2005·Archives of Pharmacal Research·Eun-Seok ParkSang-Cheol Chi
Jun 1, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Femenía-FontA López-Castellano
Sep 16, 2003·International Journal of Pharmaceutics·Victor M MeidanBozena B Michniak
Feb 15, 2005·International Journal of Pharmaceutics·I CsókaI Eros
Sep 29, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Narasimha MurthySek Wen Hui
Feb 20, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P RembergO Sterner
Jul 18, 2003·AAPS PharmSci·Mohammad Al-KhaliliBozena B Michniak

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