Effect of passive smoking on the lung of young lambs

Pediatric Research
A A StecenkoR A Sauder

Abstract

The effect of passive smoking on lung histology, lung mechanics, and airway responsiveness (AR) was studied in 2-month-old lambs. Two groups of lambs were studied; 17 were exposed to cigarette smoke (CS) and 13 served as age- and sex-matched controls. Starting at 1 month of age, CS lambs had 25 daily exposures to the smoke generated from eight cigarettes. A smoking machine was constructed for the study using a Bird Ventilator. Two days prior to lung function testing, lambs were anesthetized and a Silastic balloon was placed in the pleural space for later measurement of pleural pressure. At the beginning of each study, lambs were intubated with a nasotracheal tube over a flexible fiberoptic bronchoscope. Lung mechanics (dynamic compliance, resistance of the lung, functional residual capacity) and AR were measured using a whole body plethsymograph. AR to inhaled histamine, carbachol, and citric acid was measured in each lamb on 3 separate days by giving five breaths of increasing concentrations of the aerosol in a noncumulative fashion. AR was measured both within 24 h of the final exposure to CS and at 3-7 days after CS. After the final AR was measured, lambs were anesthetized and an open lung biopsy performed. Control lambs had...Continue Reading

Citations

May 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Namho KimJung Soo Suk
May 15, 2009·International Journal of Environmental Research and Public Health·Maura Lodovici, Elisabetta Bigagli

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