Effect of Paternal Age on Reproductive Outcomes of Intracytoplasmic Sperm Injection

PloS One
Yixuan WuJianqiao Liu

Abstract

The impact of paternal age on reproduction, especially using assisted reproductive technologies, has not been well studied to date. To investigate the effect of paternal age on reproductive outcomes, here we performed a retrospective analysis of 2,627 intracytoplasmic sperm injection (ICSI) cycles performed at the Reproductive Medicine Center of the Third Affiliated Hospital of Guangzhou Medical University (China) between January 2007 and May 2015. Effect of paternal age on embryo quality [number of fertilized oocytes, 2 pronucleus zygotes (2PNs), viable embryos, and high-quality embryos] was analyzed by multiple linear regression. Relationships between paternal age and pregnancy outcomes were analyzed by binary logistic regression. After adjusting for female age, no association between paternal age and the following parameters of embryo quality was observed: number of fertilized oocytes (B = -0.032; 95% CI -0.069-0.005; P = 0.088), number of 2PNs (B = -0.005; 95% CI -0.044-0.034; P = 0.806), and number of viable embryos (B = -0.025; 95% CI -0.052-0.001; P = 0.062). However, paternal age negatively influenced the number of high-quality embryos (B = -0.020; 95% CI -0.040-0.000; P = 0.045). Moreover, paternal age had no effect on...Continue Reading

References

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Citations

Feb 28, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·F BoitrelleG Robin
Feb 3, 2018·Molecular Reproduction and Development·Ismail KaarouchOmar Sefrioui
Jul 12, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Maíra Morales BritoCamila Infantosi Vannucchi
Jul 20, 2018·Panminerva Medica·Mariana Bertoncelli TanakaSandro C Esteves
May 2, 2018·Arab Journal of Urology·Damayanthi Durairajanayagam
Apr 24, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yixuan Wu, Haiying Liu
Mar 20, 2019·Endocrine Reviews·Jean-Marc KaufmanIlpo Tapani Huhtaniemi
May 15, 2021·Zygote : the Biology of Gametes and Early Embryos·Fumiaki ItoiJun Ueda

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