Effect of peak inspiratory flow on gas exchange, pulmonary mechanics, and lung histology in rabbits with injured lungs.

Journal of Anesthesia
Yasuki FujitaMasaji Nishimura

Abstract

The aim of this study was to evaluate, using a rabbit model, the little-known effect of different levels of peak inspiratory flow on acutely injured lungs. Fourteen male rabbits (body weight, 2,711 +/- 146 g) were anesthetized and their lungs were injured by alveolar overstretch with mechanical ventilation until Pa(O(2)) was reduced below 300 mmHg. Injured animals were randomly assigned to: the P group-to receive pressure-regulated volume-control ventilation (PRVCV; n = 7); and the V group-to receive volume-control ventilation (VCV; n = 7). Other ventilator settings were: fraction of inspired oxygen (FI(O(2)), 1.0; tidal volume, 20 ml x kg(-1); positive end-expiratory pressure (PEEP) 5 cmH(2)O; and respiratory rate, 20 min(-1). The animals were thus ventilated for 4 h. Throughout the protocol, ventilatory parameters and blood gas were measured every 30 min. After the protocol, the lung wet-to-dry ratio and histological lung injury score were evaluated in the excised lungs. Throughout the protocol, peak inspiratory flow and mean inspiratory flow values in the P group were significantly higher than those in the V group (26.7 +/- 5.0 l x min(-1) vs 1.2 +/- 0.2 l x min(-1), and 4.3 +/- 0.3 l x min(-1) vs 1.1 +/- 0.1 l x min(-1); P ...Continue Reading

References

May 1, 1995·American Journal of Respiratory and Critical Care Medicine·D DreyfussG Saumon
Jan 1, 1993·Critical Care Medicine·J C ParkerK J Peevy
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Nov 22, 2000·The Journal of Trauma·P B RichR B Hirschl
Feb 24, 2001·Intensive Care Medicine·M NishimuraT Nishida
Apr 12, 2003·Critical Care Medicine·Roy G Brower, Gordon D Rubenfeld
Jun 10, 2003·Critical Care Medicine·Christopher H GossUNKNOWN ARDS Network
Jan 15, 2004·Intensive Care Medicine·John G LaffeyBrian P Kavanagh
Aug 31, 2004·The European Respiratory Journal·M KotaniY-C T Huang

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Citations

Mar 27, 2013·Critical Care : the Official Journal of the Critical Care Forum·John J Marini

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