Effect of pedunculagin investigated by non-invasive evaluation on atopic-like dermatitis in NC/Nga mice

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Onseok LeeChil Hwan Oh

Abstract

Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder that is becoming increasingly prevalent. Experimental animal models have been an indispensable tool for studying its pathological mechanisms and for in vivo testing of novel therapeutic approaches. AD-like lesions can be induced experimentally in NC/Nga mice. Pedunculagin, an ellagitannin purified from the Manchurian alder, Alnus hirsuta var. microphylla, Betulaceae, is a novel immunomodulator. To evaluate the effect of pedunculagin for AD-like lesions in NC/Nga mice, using clinical and non-invasive methods. AD-like lesions were induced in NC/Nga mice using 2,4,6-trinitrochlorobenzene (TNCB). A cream containing 0.1% or 0.5% pedunculagin was applied to the positive treatment group, and the base cream without pedunculagin was applied to the negative treatment group. The control group did not receive any kind of topical agents. We evaluated the therapeutic efficacy of pedunculagin for AD by statistical evaluation of the clinical severity score using non-invasive biomedical engineering tools before treatment, and 1 day, 3 days, 1 week, 2 weeks and 4 weeks afterwards. An AD-like skin rash was successfully induced using TNCB in NC/Nga mice. The group receiving h...Continue Reading

References

Oct 1, 1992·Journal of Biomechanics·M MridhaP A Oberg
May 1, 1990·The Journal of Allergy and Clinical Immunology·D Y LeungJ M Hanifin
Feb 13, 2001·The British Journal of Dermatology·A AioiH Matsuda
Dec 26, 2001·International Archives of Allergy and Immunology·T SasakawaH Matsuda
Jan 22, 2003·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Luis Monteiro RodriguesLuis Marcelo Pereira
Jan 22, 2003·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Yusuke YoshizawaHoward I Maibach
Jan 22, 2003·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ingrid NicanderStig Ollmar
Apr 3, 2004·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Katsuo MatsumotoHachiro Tagami
Apr 17, 2004·Experimental Dermatology·Sang Yong ParkChil-Hwan Oh
Jul 22, 2004·Journal of Dermatological Science·Min-Gi KimChil-Hwan Oh
Sep 2, 2004·Biological & Pharmaceutical Bulletin·Xiu Kun GaoHiroichi Nagai
Oct 19, 2004·Journal of Dermatological Science·Tetsuo ShioharaYoshiko Mizukawa
Nov 16, 2004·International Archives of Allergy and Immunology·Jan GutermuthThilo Jakob
Feb 5, 2005·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·A BornkesselJ W Fluhr
Jun 7, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Xiu Kun GaoHiroichi Nagai
Aug 3, 2006·Environmental Health Perspectives·Hirohisa TakanoToshikazu Yoshikawa

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Citations

Aug 30, 2013·International Journal of Nanomedicine·Eder Lilia Romero, Maria Jose Morilla
Nov 26, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·O LeeM Kim
Jun 10, 2016·Phytotherapy Research : PTR·Shefton ParkerCharlie Changli Xue

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