Effect of penicillin on an excitatory synapse.

Brain Research
K J Futamachi, D A Prince

Abstract

When penicillin, an epileptogenic agent, was applied to the neuromuscular junctions of the superficial flexor muscles of crayfish, the excitatory junctional potential (EJP) amplitudes were increased by 50-200%. This effect of the drug was not due to changes in the passive electrical properties of the muscle cell membrane or to an increase in its chemical sensitivity to acetylcholine (ACh), the presumed transmitter at the junction studied. Inactivating the penicillin with the enzyme penicillinase, or substituting acetate for penicillin in the test solutions eliminated the effect on EJPs, showing that the penicillin ion was the active agent. Penicillin ions did decrease the frequency of spontaneous miniature EJPs and increase the amplitude or presynaptic spikes recorded extracellularly, suggesting that augmentation of EJPs may have been due to alterations at the presynaptic nerve terminals.

References

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Aug 11, 1972·Brain Research·D R CurtisR M MacLachlan
Jul 1, 1971·Neurology·M J Gutnick, D A Prince
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Citations

May 1, 1977·Annals of Neurology·P A Schwartzkroin, D A Prince
Aug 1, 1979·Annals of Neurology·R C Collins, T V Caston
Jan 1, 1981·Biological cybernetics·F Pongrácz, M Szente
Jul 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·G N KryzhanovskiĭV A Zinkevich
Sep 10, 1976·Brain Research·M J GutnickN Citri
May 20, 1977·Brain Research·K R Courtney, D A Prince
May 1, 1977·Electroencephalography and Clinical Neurophysiology·R S Fisher, D A Prince
May 1, 1979·Electroencephalography and Clinical Neurophysiology·T E Anderson, L T Rutledge
Mar 1, 1981·Electroencephalography and Clinical Neurophysiology·A L ToweG W Harding
Jun 1, 1984·Electroencephalography and Clinical Neurophysiology·J LermaJ M Solís
Oct 24, 1985·Neuroscience Letters·M SabatinoV La Grutta
Mar 9, 2005·Journal of Zhejiang University. Science. B·Ying-Jun LuXiao-Xiang Zheng
Nov 1, 1978·Experimental Neurology·J J Hablitz, D V Wray
Dec 9, 1977·Brain Research·J L Noebels, D A Prince
May 19, 1978·Brain Research·P A Schwartzkroin, D A Prince

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