Effect of penicillin resistance on presentation and outcome of nonenterococcal streptococcal infective endocarditis

Cardiology
Ron-Bin Hsu, Fang-Yue Lin

Abstract

Most cases of infective endocarditis are caused by nonenterococcal streptococci. The emergence of strains resistant to penicillin is increasingly recognized worldwide. This study sought to assess the effect of penicillin resistance on presentation and outcome of streptococcal endocarditis. A retrospective study was conducted in a single tertiary care hospital. Between August 1996 and December 2004, patients infected with nonenterococcal streptococcal endocarditis and known minimal inhibitory concentrations (MICs) to penicillin were included in this study. A total of 62 cases were identified: 48 (77%) cases of the streptococcal endocarditis were caused by viridans streptococci. The most common species groups identified were Streptococcus mitis in 12 (19%) cases, Streptococcus oralis in 9 (15%) cases, Streptococcus sanguis in 7 (11%) cases and Streptococcus mutans in 7 (11%) cases. There were 36 male and 26 female patients with a median age of 46 years (range: 1-85). Twenty-two patients (35%) had peripheral embolization and 10 patients (16%) died in hospital. Twenty-eight (45%) of the 62 patients were infected with streptococcal strains of MICs > or =0.125 microg/ml to penicillin. Infection with streptococcal strains of MICs > or...Continue Reading

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May 25, 2007·Nature Clinical Practice. Cardiovascular Medicine·Isil BavunogluAydin Tunckale
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Nov 22, 2007·The American Journal of the Medical Sciences·Cheng-Hsin Lin, Ron-Bin Hsu
Jan 10, 2012·Enfermedades infecciosas y microbiología clínica·Nuria Fernández-Hidalgo, Benito Almirante
Sep 7, 2021·The Journal of Antimicrobial Chemotherapy·Clara FlateauSylvain Diamantis

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