PMID: 6171486Nov 1, 1981Paper

Effect of pentagastrin on histamine output from the stomach in patients with duodenal ulcer

Gut
W ManJ Spencer

Abstract

The role of histamine in acid secretion is controversial. Improvements in the techniques of histamine assay allow a better assessment of the relationship of histamine to acid secretion. Patients with duodenal ulcers were studied to determine the mucosal histamine responses to pentagastrin stimulation to relate the appearance of histamine in the gastric juice to acid production during stimulation, and to detect changes in the plasma histamine concentration during pentagastrin stimulation. There was a mean 27% fall (range 0-60%) in mucosal histamine concentration after pentagastrin. The output of histamine into gastric juice closely paralleled acid output in peak output acid duration. The histogram profiles of acid and histamine were similar in shape. In contrast with previous studies, plasma histamine concentration was found to rise during peak acid secretion (mean rise 65%). There was no relationship between initial mucosal histamine concentration and acid secretion or maximal gastric juice histamine. The association of histamine and gastric acid release found in these studies was so close that a functional relationship may be presumed. Our data are compatible with the hypothesis that pentagastrin acts on the parietal cell indi...Continue Reading

Citations

Apr 1, 1984·Agents and Actions·W K ManJ Spencer
May 1, 1991·Agents and Actions·D E WithingtonW K Man
Apr 1, 1988·Agents and Actions·A MarathA Kimberley
Apr 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D E WithingtonM J Elliott
Apr 7, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN American College of Allergy, Asthma, & Immunology
Jul 27, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David N Perkins, Paul K Keith
Mar 1, 1990·The British Journal of Radiology·W K ManA S Michalowski
Mar 1, 1989·Scandinavian Journal of Gastroenterology·H L Waldum, A K Sandvik
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Dec 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·H LönrothL Lundell
Feb 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·H LönrothE Rosengren
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Oct 1, 1994·European Journal of Clinical Investigation·A S Pappu, D R Illingworth
Nov 26, 2014·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·M-C Fischer, A Meyer-Lindenberg
Aug 1, 1992·Scandinavian Journal of Gastroenterology·A Courillon-MalletD Cattan
Jan 1, 1993·Anaesthesia·D E WithingtonF Reynolds

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