PMID: 9546416Apr 18, 1998Paper

Effect of pentoxifylline on cytokine patterns in the therapy of complicated Plasmodium falciparum malaria

The American Journal of Tropical Medicine and Hygiene
C WenischW Graninger

Abstract

The effect of pentoxifylline (PTX) was tested for its capacity to modulate cytokine responses during therapy of severe Plasmodium falciparum malaria in a placebo-controlled, randomized study in 45 adult patients in Bangkok, Thailand. The patients received standard antimalarial treatment with artesunate (120 mg intravenously given immediately, then 60 mg every 12 hr for a total dose of 600 mg). The patients received either low-dose PTX (20 mg/kg/day, n = 15), high-dose PTX (40 mg/kg/day, n = 15), or placebo (n = 15) as continuous infusion for the first three days of antimalarial treatment. Tumor necrosis factor (TNF) and interleukin-6 (IL-6) plasma levels were markedly elevated in all patients prior to treatment. After 6 hr of high-dose PTX treatment, TNF and IL-6 levels significantly decreased while an increase in TNF and IL-6 levels was seen after 6 hr of low-dose PTX or placebo treatment (P < 0.01). After 12 and 24 hr of high-dose PTX infusion, TNF-receptor plasma concentrations were lower than in low-dose PTX- or placebo-treated patients (P < 0.01), whereas no differences between the groups with regard to IL-6 receptor levels were observed. We conclude that 40 mg/kg/day of PTX reduces plasma levels of TNF, IL-6, and TNF-rece...Continue Reading

Citations

Dec 21, 2000·Parasite Immunology·D MazierM Idrissa-Boubou
Jul 25, 2020·Malaria Journal·Nicoline SchiessMonique F Stins
Dec 24, 2010·Malaria Journal·Bertrand LellCharles R J C Newton
Jul 19, 2003·Tropical Medicine & International Health : TM & IH·B K DasB Ravindran
Feb 6, 1999·Critical Care Medicine·M P Fink
May 11, 2017·Journal of Renal Injury Prevention·Heshmatolah ShahbazianGholam Reza Lashkarara
Sep 13, 2011·Expert Review of Anti-infective Therapy·Sarah J HigginsW Conrad Liles
Nov 6, 2009·Der Anaesthesist·H V GroesdonkH Heinze
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gianni BioloGianfranco Guarnieri

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