Effect of Pentoxifylline on Histological Activity and Fibrosis of Nonalcoholic Steatohepatitis Patients: A One Year Randomized Control Trial

Journal of Translational Internal Medicine
Shahinul AlamNooruddin Ahmad

Abstract

To observe the effect of Pentoxifylline for 1 year on hepatic histological activity and fibrosis of nonalcoholic steatohepatitis (NASH). A single center, open label Randomized Control Trial. Patients were included if they had ultrasonographic evidence of fatty liver and nonalcoholic fatty liver disease activity score (NAS) ≥ 5 on liver histology. A total of 35 patients were selected; 25 of PL (Experimental) group and 10 of L (Control) group. PL group received 400 mg pentoxifylline thrice daily along with lifestyle modification and there was only lifestyle modification for the L group. After one year, NAS and fibrosis was compared in both groups. In PL group, NAS improved 2.10 ± 1.07; whereas in L group, NAS was 0.90 ± 0.99 (P = 0.006). As per the protocol analysis, NAS ≥ 2 improved in 15/20 (75%) in PL group and in 3/10 (30%) in L group (P = 0.018). In PL group, the individual component of NAS, steatosis improved from 2.30 ± 0.66 to 0.95 ± 0.76 (P = 0.000), lobular inflammation from 1.65 ± 0.59 to 1.05 ± 0.51 (P = 0.002) and hepatocyte ballooning from 1.50 ± 0.51 to 1.30 ± 0.57 (P = 0.258). In L group, steatosis improved from 2.30 ± 0.68 to 1.40 ± 1.08 (P = 0.01), lobular inflammation and hepatocyte ballooning did not improve. ...Continue Reading

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Citations

Mar 7, 2019·The American Journal of Gastroenterology·Amanda CheungMary E Rinella
Oct 23, 2019·Journal of Translational Internal Medicine·Shahinul AlamNazmul Hasan
Jun 17, 2020·Expert Opinion on Pharmacotherapy·Joeri LambrechtFrank Tacke
Jun 1, 2019·Pharmacology Research & Perspectives·Manca PovsicJuliana Bottomley
Dec 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Anna RoskillyIan A Rowe
Oct 15, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·David S H Bell

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