Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model

Fertility and Sterility
Nikos F VlahosGeorge Creatsas

Abstract

To investigate the effects of pentoxifylline, on vascular endothelial growth factor (VEGF)-C and flk-1 expression in the rat endometriosis model. Prospective, randomized, placebo-controlled study. Academic institution. Twenty Wistar rats with surgically induced endometriosis. Animals were evaluated after surgical induction of endometriosis and random allocation to a group that received pentoxifylline and a control group that received NaCl 0.9%, for 3 weeks. At the end of the treatment period the animals were killed and the implants evaluated macroscopically as well as by immunohistochemistry. Morphologic changes of the endometriotic implants; and evaluation of VEGF-C and flk-1 expression by a semiquantitative analysis (HSCORE) for the intensity of immunohistochemical reactivity. A significant reduction was observed in the mean volume of the endometriotic implants per animal in the treatment group as compared with the control group. There was a significant reduction not only in the mean volume of implants per animal but also in the mean number of implants per animal after treatment. By immunohistochemical evaluation (HSCORE), there was a significant reduction in VEGF-C expression after treatment in all areas examined. A signific...Continue Reading

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Fràter-SchröderP Böhlen
Dec 23, 1989·Lancet·P ZabelU F Schade
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·B J DezubeA B Pardee
Mar 1, 1994·American Journal of Reproductive Immunology : AJRI·W B NothnickM W Vernon
Dec 1, 1995·American Journal of Reproductive Immunology : AJRI·J A KeenanM R Caudle
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G AchenS A Stacker
Aug 4, 1998·Human Reproduction·J DonnezM Nisolle
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·B OlofssonU Eriksson
Mar 11, 2000·Human Reproduction Update·J McLaren
Feb 13, 2001·Fertility and Sterility·D I LebovicR N Taylor
Oct 16, 2001·Journal of Cancer Research and Clinical Oncology·R P GudeR D Bonfil
Apr 13, 2002·Annals of the New York Academy of Sciences·Robert N TaylorMichael D Mueller
Sep 6, 2002·The American Journal of Pathology·Charlotta DabrosinJack Gauldie
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·M Louise HullStephen K Smith
Oct 7, 2005·Archives of Gynecology and Obstetrics·Pedro XavierHenrique Barros
Feb 12, 2008·Journal of Minimally Invasive Gynecology·Huse Kamencic, John A Thiel
Jul 7, 2011·The International Journal of Developmental Biology·Silvia NuceraMichele De Palma

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Citations

Jun 22, 2012·Human Reproduction Update·M W Laschke, M D Menger
Jul 11, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Zhulanqiqige Do eHiroaki Shimokawa
Aug 29, 2014·BioMed Research International·Gabriella ZitoGiuseppe Ricci
Sep 1, 2015·Women's Health·Rukset Attar, Erkut Attar
Aug 19, 2014·The Journal of Obstetrics and Gynaecology Research·Afshin AzimiradMina Azimirad
Aug 11, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zehra Sema ÖzkanBilge Aydin Turk
Sep 4, 2012·Fertility and Sterility·Sérgio Reis SoaresAntonio Pellicer
Oct 16, 2016·Reproductive Sciences·Maria PerellóFrancisco Carmona
May 26, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Anastasia ProdromidouDespina N Perrea
Dec 21, 2018·Molecular Medicine Reports·Jia HuBu-Zhen Tan
Jun 1, 2017·Reproductive Sciences·Maria PerellóFrancisco Carmona
May 26, 2021·Obstetrical & Gynecological Survey·Nikolaos ThanatsisApostolos Kaponis
Aug 26, 2021·The Cochrane Database of Systematic Reviews·Alexandros Loukas GrammatisChristian M Becker
Jul 16, 2021·Minerva Obstetrics and Gynecology·Alexis L NewmarkAnthony A Luciano

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