PMID: 8978740Jan 1, 1997Paper

Effect of pentylenetetrazole-induced kindling on acetylcholine release in the hippocampus of freely moving rats

Journal of Neurochemistry
M SerraG Biggio

Abstract

The role of gamma-aminobutyric acid (GABA) modulation of septohippocampal cholinergic neurons in kindling was investigated. Hippocampal acetylcholine release was evaluated with the microdialysis technique in freely moving rats either after acute administration of isoniazid (an inhibitor of GABA synthesis) or pentylenetetrazole (PTZ) (a blocker of the GABAA receptor-associated Cl- channel) or after chronic administration of PTZ. Short-term treatment with PTZ (5-50 mg/kg, i.p.) or isoniazid (150-250 mg/kg, s.c.) increased hippocampal acetylcholine release in a dose-dependent manner. In contrast, the basal concentration of acetylcholine in the dialysate from the hippocampus of rats chronically treated with PTZ (kindled animals) was significantly reduced relative to that of vehicle-treated rats (2.39 +/- 0.21 vs. 4.2 +/- 0.31 pmol per 20-min sample; p < 0.01). Moreover, the release of acetylcholine was markedly more sensitive to the effect of a challenge injection of PTZ (10 or 20 mg/kg, i.p.) in kindled rats than in naive rats or rats chronically treated with vehicle. Abecarnil, a selective benzodiazepine receptor agonist with marked anticonvulsant activity, was administered together with chronic PTZ to evaluate whether persistent...Continue Reading

Citations

Jun 4, 2014·Basic & Clinical Pharmacology & Toxicology·Awanish Mishra, Rajesh Kumar Goel
Oct 9, 2013·Neurochemical Research·Awanish Mishra, Rajesh Kumar Goel
Sep 1, 2007·Behavioural Pharmacology·Carla M YuedeJohn G Csernansky
Feb 8, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Hisayoshi IshiiHiroshi Izumi

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