Effect of peptide agonists of peripheral opioid receptors on operant feeding behavior and food motivation in rats

Bulletin of Experimental Biology and Medicine
N G BogdanovaS K Sudakov

Abstract

We studied the effect of intragastric administration of peptide agonists of μ-opioid receptors (DAMGO) and δ-opioid receptors (DADLE) on food consumption and food motivation during operant feeding behavior of different intensity and effectiveness. To obtain one food granule, trained rats should press a lever 1 time (day 1), 2 times (day 2), 4 times (day 3), 8 times (day 4), 16 times (day 5), or 32 times (day 6). Activation of δ-opioid receptors in the stomach was followed by suppression of feeding behavior at low energy expenditure. The level of food motivation under these conditions practically did not differ from the control. Activation of μ-opioid receptors in the stomach suppressed energy-consuming feeding behavior, which was accompanied by an increase in the level of food motivation. It can be hypothesized that protein metabolites exhibiting μ-opioid activity probably provide afferent signals into CNS via the vagus nerve to terminate energy expenditure under adverse conditions (although food motivation is not satisfied). Food motivation under these conditions probably contributes to the behavior aimed towards the search for more available food.

References

Jun 11, 2009·Bulletin of Experimental Biology and Medicine·S K Sudakov, M M Trigub
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B A Gosnell, A S Levine
Jul 15, 2009·Neuropharmacology·Soichiro IdeKumatoshi Ishihara
Jan 24, 2012·Bulletin of Experimental Biology and Medicine·Yu A ChumakovaS K Sudakov
Nov 1, 2012·Bulletin of Experimental Biology and Medicine·S K SudakovN N Chernyaeva
Nov 1, 2012·Bulletin of Experimental Biology and Medicine·E V AlexeevaS K Sudakov
May 16, 2014·Bulletin of Experimental Biology and Medicine·M M TrigubS K Sudakov
Jan 13, 2015·Bulletin of Experimental Biology and Medicine·S K SudakovA A Kolpakov

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Citations

Apr 26, 2019·Bulletin of Experimental Biology and Medicine·S K Sudakov
Jan 30, 2021·Frontiers in Behavioral Neuroscience·Sergey Sudakov, Natalia Bogdanova

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