Effect of peptides of bovine myelin basic protein on dermal fibroblasts

Journal of Neuroscience Research
T M ChiangA H Kang

Abstract

Bovine basic protein (BP) was digested with purified bovine brain cathepsin D to produce well defined BP derived peptides 1-42, 43-88, 43-169, and 89-169. BP and these BP peptides were tested for their effects on cultured human dermal fibroblasts using a concentration range of 0.01-1,000 ng/ml. No effect was found on cellular proliferation, and neither total protein nor collagen synthesis was altered in the presence of these substances. Although preparations of brain which contain a fibroblast-growth factor also contain BP peptides, these results indicate that the purified BP peptides studied have no detectable biological effect on the growth of human dermal fibroblasts.

References

Aug 1, 1977·The Journal of Experimental Medicine·J N WhitakerR F Kibler
Apr 1, 1975·European Journal of Biochemistry·M BenuckG A Hashim
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F C WestallD Gospodarowicz
Nov 1, 1978·Cell·M C RaffA Hornby-Smith
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S Cohen, G Carpenter
Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H N AntoniadesC D Scher
Jan 1, 1975·Advances in Metabolic Disorders·B Westermark, A Wasteson

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Citations

Mar 15, 1982·Thrombosis Research·T M ChiangE H Beachey
Oct 1, 1982·The Journal of Cell Biology·S K LemmonR A Bradshaw
Aug 7, 1983·Journal of Theoretical Biology·F C Westall
Jun 16, 1982·Biochimica Et Biophysica Acta·T Hatahara, J M Seyer
Jun 16, 1982·Biochimica Et Biophysica Acta·T Hatahara, J M Seyer

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