Effect of percutaneous nephrolithotripsy on renal function: assessment with quantitative SPECT of (99m)Tc-DMSA renal scintigraphy

Journal of Endourology
B MoskovitzO Nativ

Abstract

To measure the effect of PCNL on global and regional renal function using quantitative single-photon emission CT (SPECT) measurement of Tc-dimercaptosuccinic acid (DMSA) uptake by the kidneys (QDMSA). A series of 47 male and 41 female patients with a mean age of 47 +/- 16 years were studied by sequential QDMSA examinations before and 1.5 to 24 months after PCNL. Among the 67 patients (76%) in whom PCNL was performed using upper- or lower-pole access, the function of the affected and nonaffected poles of the treated kidney was calculated separately. There was no statistically significant difference in the uptake by the treated kidneys before versus after PCNL (11.9% +/- 5% v 11.6% +/- 5%; t = 0.9; P = 0.368). The total functional volume of the treated kidney was slightly decreased, from 235 cc +/- 62 cc to 224 cc +/- 59 cc (t = 2.7; P = 0.011). The percent of the injected isotope dose per cubic centimeter of tissue of the treated kidney was not affected (0.051 +/- 0.02 v 0.053 +/- 0.02; t = 0.86; P = 0.296). Regional assessment revealed a statistically significant decrease in the functional volume at the PCNL port of entry (91 cc +/- 30 cc v 82 cc +/- 27 cc; t = 2.64; P = 0.013). Regarding the percent of the injected dose per cu...Continue Reading

Citations

Sep 8, 2010·Journal of Endourology·Uwais B Mufti, Sarath K Nalagatla
Dec 30, 2014·Advanced Biomedical Research·Mehrdad Mohammadi SichaniMohammad Hossein Izadpanahi
Dec 21, 2010·BJU International·Ahmed R El-NahasMahmoud R El-Kenawy
May 26, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Xuefang RuiZhigen Zhang
Feb 23, 2010·The Journal of Urology·Emrah YurukAhmet Tefekli
Apr 23, 2020·Current Urology Reports·Thomas ReevesBhaskar K Somani
Nov 18, 2017·Urolithiasis·Daniel A Wollin, Glenn M Preminger
Feb 24, 2021·International Journal of Clinical Practice·Mehmet Cagatay CicekHakan Kilicarslan

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