PMID: 11910650Mar 26, 2002Paper

Effect of perimenopause on calcium absorption: a longitudinal study

Climacteric : the Journal of the International Menopause Society
J M WishartB E Nordin

Abstract

Cross-sectional studies suggest that the rise in calcium requirement at the menopause may be attributable, at least in part, to a fall in intestinal calcium absorption. The aim of the present study was to determine the effect of the menopause on intestinal calcium absorption and the relationship between any change in calcium absorption and serum calcitriol. Radiocalcium absorption and serum calcitriol were measured in 72 women aged 47.3 (standard error, SE 0.19) years who were initially premenopausal (as judged by menstrual history and serum follicle stimulating hormone (FSH)) and again 18 months later. Calcium absorption fell at the second visit from 0.72 (0.029)/h to 0.64 (0.029)/h (p = 0.003). Serum calcitriol had also fallen at the second visit from 124 (4.2) pmol/l to 111 (4.0) pmol/l (p = 0.007). At that visit, serum FSH exceeded the premenopausal reference range in 11 subjects and the menstrual cycle had become irregular in 24 of them. In the 11 women with raised FSH at the second visit, radiocalcium absorption fell from 0.85/h (0.097) at baseline to 0.57/h (0.049) (p = 0.008), but only from 0.70/h (0.028) to 0.65/h (0.033) (not significant) in the remaining 61. Similarly, radiocalcium absorption fell significantly (p = ...Continue Reading

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Citations

Nov 5, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B E Christopher NordinHoward A Morris
Jan 28, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A ShapsesL Taich
Feb 22, 2012·Breast Cancer Research and Treatment·Amye TevaarwerkKaren E Hansen
Jan 14, 2010·Clinical Pharmacokinetics·Teun M PostMeindert Danhof
May 10, 2003·Journal of Women's Health·Alan O Malabanan, Michael F Holick
Feb 28, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karen E HansenMartin M Shafer
Jun 24, 2004·Clinical Endocrinology·B E Christopher NordinMichael Horowitz
Sep 28, 2004·The American Journal of Clinical Nutrition·B E Christopher NordinMichael Horowitz

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