Effect of perinatal exposure to Bisphenol-A on DNA methylation and histone acetylation in cerebral cortex and hippocampus of postnatal male mice

The Journal of Toxicological Sciences
Dhiraj Kumar, Mahendra K Thakur

Abstract

Bisphenol-A (BPA) is an estrogenic endocrine disruptor mostly used for the production of polycarbonate plastics and epoxy resins. Recently we have reported that perinatal BPA exposure impaired spatial memory through upregulation of synaptic proteins Neurexin1 and Neuroligin3 in male mice. As epigenetic mechanism is a key regulator of memory, we hypothesized that BPA might influence memory through epigenetic regulation of gene expression. Here we provide evidence that perinatal exposure to BPA decreased 5-mC DNA but increased histone H3 acetylation in cerebral cortex and hippocampus of postnatal 3 and 8 weeks male mice. BPA exposure also increased mRNA levels of DNMT1 and DNMT3a in cerebral cortex of 3 and 8 weeks; whereas in hippocampus DNMT1 mRNA increased in 3 weeks but decreased in 8 weeks and DNMT3a showed no change. Further, HDAC2 mRNA and protein increased in cerebral cortex of both ages and in hippocampus it increased in 3 weeks but decreased in 8 weeks. Altogether, our results demonstrate that the perinatal BPA exposure induces epigenetic changes that possibly underlie the enduring effect of BPA on brain function and behavior.

References

Dec 11, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·V BarresiA M Giuffrida Stella
Jan 3, 2001·Brain Research·J H BoatrightD E Borst
Jan 31, 2002·Dental Materials Journal·K SuzukiF Nishimura
Apr 3, 2003·Nature Reviews. Molecular Cell Biology·Siavash K Kurdistani, Michael Grunstein
Jan 27, 2005·Journal of Neuroscience Research·Jian FengGuoping Fan
Jan 24, 2006·Journal of Biochemistry·Akatsuki KimuraMasami Horikoshi
Dec 26, 2006·Current Opinion in Pharmacology·Mark S AnsorgeJay A Gingrich
Feb 27, 2007·Cell·Aaron D GoldbergEmily Bernstein
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
Jan 15, 2008·Molecular and Cellular Endocrinology·Wei ZhouJinyong Liu
Sep 23, 2008·Biochemical and Biophysical Research Communications·Takeshi YaoiShinji Fushiki
Sep 18, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jamie R WeaverMarisa S Bartolomei
Oct 16, 2009·Biology of Reproduction·Cheryl S Rosenfeld
Feb 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason G BromerHugh S Taylor
Mar 27, 2010·Environmental Health Perspectives·Laura N VandenbergGilbert Schoenfelder
Aug 24, 2010·Nature Neuroscience·Quincey LaPlantEric J Nestler
Dec 7, 2010·General and Comparative Endocrinology·B MigliariniO Carnevali
Jan 26, 2011·Nature Reviews. Endocrinology·Deena M Walker, Andrea C Gore
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga
Mar 1, 2012·Current Alzheimer Research·N H Zawia, D K Lahiri
Jun 7, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucia Peixoto, Ted Abel
Jun 19, 2012·Endocrinology·Jennifer T WolstenholmeJessica J Connelly
Feb 19, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bhavini B PatelLorraine E Chalifour
Mar 22, 2014·The Journal of Toxicological Sciences·Tetsuji NagaoMunekazu Komada

❮ Previous
Next ❯

Citations

Jan 18, 2020·Environmental Health Perspectives·Felicia Fei-Lei Chung, Zdenko Herceg
Oct 28, 2019·Frontiers in Genetics·Maureen A MalloyLaurie K Svoboda
Aug 5, 2017·Frontiers in Molecular Neuroscience·Ernesto Miranda-MoralesOscar Arias-Carrión
Aug 1, 2019·Current Neuropharmacology·Antonietta SantoroRosaria Meccariello
Dec 9, 2020·Nature Reviews. Endocrinology·David Lopez-RodriguezAnne-Simone Parent
Dec 10, 2020·Oxidative Medicine and Cellular Longevity·Dinh Nam TranEui-Bae Jeung
Jan 22, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Vian PeshdaryElla Atlas
Mar 5, 2021·Biological Reviews of the Cambridge Philosophical Society·Marta Lombó, Paz Herráez
May 26, 2018·Chemical Research in Toxicology·Manoj SonavaneNatalie R Gassman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.