Effect of periodontitis on cardiovascular manifestations in Marfan syndrome. Critical common role of TGF-β

International Heart Journal
Jun-ichi SuzukiYasunobu Hirata

Abstract

Marfan syndrome (MFS) is a systemic connective tissue disorder that is caused by mutations in the extracellular matrix protein fibrillin-1. While MFS patients are considered to be at high risk of dental disorders and cardiovascular complications, little causal relationship has been provided to date. It is well known that an elevated level of active TGF-β in the plasma is a major manifestation of MFS. TGF-β is known to play a critical role in the development of cardiovascular diseases and its levels were also elevated in the serum and saliva of periodontitis patients. These findings may suggest an association between periodontitis and the cardiovascular complications of MFS. In this article, we review the influence of periodontitis in MFS patients with cardiovascular complications in order to identify critical therapeutic targets of TGF-β.

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Citations

Apr 4, 2016·Cryobiology·Jian ZhangHuishan Wang
Jul 8, 2016·International Heart Journal·Jun-Ichi SuzukiYasunobu Hirata
Aug 3, 2018·International Heart Journal·Hiroshi Akazawa
Oct 3, 2017·International Heart Journal·Rungtiwa SrisuwanthaJun-Ichi Suzuki
Jan 8, 2020·The Journal of Oral Implantology·Ahmad KutkutMohanad Al-Sabbagh
Jul 1, 2020·Current Problems in Cardiology·Michael P SeitzYenal Harper

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