Effect of perioperative steroid therapy on the postoperative course of patients with oesophageal cancer

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
K TsukadaH Kuwano

Abstract

Perioperative steroid therapy is often used in oesophageal cancer surgery and we evaluate the effect of this therapy on the secretory leukocyte protease inhibitor levels in the lungs (a major antiprotease in the conducting airways) and postoperative course in oesophageal cancer patients. Twenty-one patients operated on for oesophageal cancer in 2003-2004 were treated with perioperative steroid therapy (250 mg of methylprednisolone intravenously 1 h before the operation). Fifteen consecutive patients operated on in 2002 served as a control group. Secretory leukocyte protease inhibitor in bronchoalveolar lavage fluid and the postoperative course in the two groups were compared. The mortality rate was 0% and there was no significant difference in the morbidity rate between the two groups. Days of intubation and systemic inflammatory response syndrome were significantly shorter for the steroid group. The bronchoalveolar lavage fluid secretory leukocyte protease inhibitor level was significantly higher in the steroid group than in the control group on postoperative days 2 and 3. The secretory leukocyte protease inhibitor level on postoperative day 3 was remarkably lower for the patients intubated for > or = 5 days and for those with...Continue Reading

References

Dec 1, 1982·The British Journal of Surgery·K SugimachiA Zaitsu
Nov 21, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S SauerlandE A Neugebauer
Nov 21, 2002·The Annals of Thoracic Surgery·Yingjie Cui

❮ Previous
Next ❯

Citations

Mar 17, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Edgard Engelman, Cécile Maeyens
May 3, 2008·Expert Review of Medical Devices·Makoto KobayashiAkinori Takagane
Jul 5, 2008·Cancer Cell·Francesca BernassolaGerry Melino
Dec 23, 2009·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Sarath SistlaSujatha Sistla
Aug 13, 2011·The Cochrane Database of Systematic Reviews·David L StewardJareen Meinzen-Derr
Aug 5, 2011·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·E A DiakosH Mehanna
Aug 31, 2013·Journal of Drug Targeting·Tianyu Liu, Qingyong Li
Oct 22, 2019·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Tadashi MatsuokaKenji Kobayashi
Nov 9, 2017·Phytopathology·Churamani KhanalSalliana R Stetina
Oct 26, 2018·Plant Disease·Jared P JensenGregory L Tylka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.