PMID: 9187462Jan 1, 1997Paper

Effect of peritoneal fluid from patients with mild and severe endometriosis on endometrial stromal cell proliferation

Archives of Gynecology and Obstetrics
Gabriela F MeresmanL S Rumi

Abstract

The aim of this study was to evaluate and compare the mitogenic effect of peritoneal fluid (PF) from women with mild and severe endometriosis on the endometrial stromal cell proliferation. Increasing concentrations of PF from women with and without mild or severe endometriosis were added to primary endometrial stromal cell cultures and 3H-thymidine incorporation was used to assess DNA synthesis in these cultures. PF from women with mild endometriosis induced a statistically significant dose-dependent increase in stromal cell thymidine uptake ranged from 5.8 to 14.5 fold, whereas PF from women with severe endometriosis produced an average 51% inhibition of stromal cell proliferation of compared with cells exposed to non-endometriosis PF or exposed to nutrient medium supplemented with 2.5% calf serum alone. PF samples from patients with stage I endometriosis induced a statistically dose-dependent increase in stromal cell proliferation, whereas PF from patients with stage IV endometriosis caused a significant inhibition.

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Citations

Oct 23, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Daniela MadanesAnalía G Ricci
Sep 1, 2017·American Journal of Reproductive Immunology : AJRI·Ruiying DiaoYong-Gang Duan
Oct 29, 2020·Reproductive Biomedicine Online·Tugba Ekiz-YilmazElif Guzel

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