Effect of peritoneal lavage with taurolidine on primary colonic anastomosis in a rat model of secondary peritonitis.

Surgery Today
Aşkin AkkuşNagihan Ozdemir Barişik

Abstract

The reported antibacterial, antiendotoxic, and antiadhesive effects of taurolidine prompted us to study the benefits of intraperitoneal lavage with taurolidine on primary colonic anastomosis in a rat model of secondary peritonitis. We induced peritonitis in 40 rats by injecting Escherichia coli isolate intraperitoneally. We performed colonic resection and primary anastomosis 5 h later, after lavage with either taurolidine or saline solution. After the rats were killed, on postoperative day (POD) 3 (n = 10) or 7 (n = 10), we measured the bursting pressures and hydroxyproline levels, then examined the resected specimens histologically. Bursting pressures and tissue hydroxyproline levels were significantly higher in the taurolidine group than in the control group on PODs 3 and 7 (P < 0.05). Histopathological examination revealed significantly higher fibroblastic activity in the taurolidine group. The higher bursting pressures and tissue hydroxyproline levels in the rats given taurolidine showed the positive effect of taurolidine on anastomotic strength in secondary peritonitis. Taurolidine is a novel antibiotic with both antibacterial and antiendotoxic effects. Intraperitoneal lavage with taurolidine solution may reduce the risks ...Continue Reading

References

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Citations

Nov 23, 2006·International Journal of Colorectal Disease·Helge FrielingDragan Pavlovic
Sep 4, 2008·American Journal of Veterinary Research·Jennifer M SimpsonAlix I Gitelman
Dec 29, 2007·The British Journal of Surgery·P K SharmaR J Ploeg
May 28, 2016·World Journal of Gastrointestinal Surgery·Malene NerstrømMagnus S Ågren
Oct 23, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Paulo Roberto Rodrigues BicalhoFabiola Alves Reis
Dec 21, 2017·Skin Pharmacology and Physiology·Axel KramerOjan Assadian

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