Effect of PET/CT standardized uptake values on complete response to treatment before definitive chemoradiotherapy in stage III non-small cell lung cancer

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Ozlem ErcelepF Yumuk

Abstract

The standard treatment for patients with stage III non-small cell lung cancer (NSCLC), unsuitable for resection and with good performance, is definitive radiotherapy with cisplatin-based chemotherapy. Our aim is to evaluate the effect of the maximum value of standardized uptake values (SUVmax) of the primary tumor in positron emission tomography-computed tomography (PET/CT) before treatment on complete response (CR) and overall survival. The data of 73 stage III NSCLC patients treated with concurrent definitive chemoradiotherapy (CRT) between 2008 and 2017 and had PET/CT staging in the pretreatment period were evaluated. ROC curve analysis was performed to determine the ideal cut-off value of pretreatment SUVmax to predict CR. Median age was 58 years (range 27-83 years) and 66 patients were male (90.4%). Median follow-up time was 18 months (range 3-98 months); median survival was 23 months. 1-year overall survival (OS) rate and 5-year OS rate were 72 and 19%, respectively. Median progression-free survival (PFS) was 9 months; 1-year PFS rate and 5-year PFS rate were 38 and 19%, respectively. The ideal cut-off value of pretreatment SUVmax that predicted the complete response of CRT was 12 in the ROC analysis [AUC 0.699 (0.550-0.8...Continue Reading

References

Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael P Mac ManusDavid L Ball
Nov 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·S M EschmannR Bares
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Corneline J HoekstraOtto S Hoekstra
Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thierry BerghmansUNKNOWN European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project
Feb 28, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Boone GoodgameRamaswamy Govindan
Dec 23, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael MacManusBranislav Jeremic
Aug 25, 2009·The Annals of Thoracic Surgery·Ikenna C OkerekeMalcolm M DeCamp
Nov 6, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Viswam S NairMichael K Gould
Mar 18, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marianne PaesmansUNKNOWN European Lung Cancer Working Party, and on behalf of the IASLC Lung Cancer Staging Project
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Jan 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jose L Lopez GuerraZhongxing Liao
Aug 11, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wouter van ElmptDirk De Ruysscher
May 23, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giovanni FaveroJesus Paula Carvalho
Sep 7, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Hyung-Jun ImDong Soo Lee
Dec 4, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nitin OhriChandan Guha
Feb 18, 2015·Journal of the National Cancer Institute·Nitin OhriMaria Werner-Wasik
Mar 2, 2017·World Journal of Clinical Oncology·Stephanie M YoonMark Hallman

❮ Previous
Next ❯

Citations

May 7, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Rudolf M HuberMichael Flentje

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.