Jan 1, 1989

Effect of PGI2 and thromboxane antagonist on liver ischemic injury

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
T BesseL Lambotte

Abstract

Thromboxane, prostacyclin and their ratio could play an important role in the ischemic liver injury. To study this hypothesis, thromboxane and prostacyclin were measured by RIA after incubation of liver tissues removed during and after an ischemia of 90 min in male Wistar rats. The thromboxane to prostacyclin ratio increases during this period. In order to examine if this change could influence the survival rate of animals submitted to the same period of ischemia, drugs able to reduce the relative predominance of thromboxane were infused. The survival rate was not modified by administration of Iloprost or Daltroban, the antagonist of the thromboxane receptors. By contrast, imidazole, an inhibitor of thromboxane synthetase, significantly increased the survival rate. The same result was obtained with the administration of Daltroban plus Iloprost, suggesting that the reduction of thromboxane action associated with the increase of PGI2 level reduces the ischemic injury.

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Mentioned in this Paper

Ischemia
August Rats
SKF 96148
Ventavis
Flolan
Sulfonamides
Phenylacetic Acids
Imidazoles
Imidazole sodium
6-Ketoprostaglandin F1 alpha

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