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Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups

Biochemistry

Nov 18, 1975

C W Garner, F J Behal

Abstract

The presence of at least two ionizable active center groups has been detected by a study of the effect of pH upon catalysis of hydrolysis of L-alanyl-beta-naphthylamide by human liver alanine aminopeptidase and upon the inhibition of hydrolysis by inhibitors and substrate analogs. Octan...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Abufne
Aminopeptidase
Metabolic Inhibition
Analogs & derivatives
Leucine
Liver
Mathematics
Analog
Inhibitors
49
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Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups

Biochemistry

Nov 18, 1975

C W Garner, F J Behal

PMID: 38

DOI: 10.1021/bi00694a009

Abstract

The presence of at least two ionizable active center groups has been detected by a study of the effect of pH upon catalysis of hydrolysis of L-alanyl-beta-naphthylamide by human liver alanine aminopeptidase and upon the inhibition of hydrolysis by inhibitors and substrate analogs. Octan...read more

Mentioned in this Paper

Hydrogen-Ion Concentration
Abufne
Aminopeptidase
Metabolic Inhibition
Analogs & derivatives
Leucine
Liver
Mathematics
Analog
Inhibitors
49
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