Jan 1, 1975

Effect of pH on the growth and cytopathogenicity of avian infectious bronchitis virus in chick kidney cells

Archives of Virology
D J Alexander, M S Collins


The growth of avian infectious bronchitis virus (IBV) in chick kidney cells at different pH values in the range 6.0-9.0 demonstrated that although the virus was released at a much faster rate at the higher pH values the titre tended to drop more quickly. At the acid pH values the virus was released more slowly but reached a maximum titre similar to that at the higher pH values and showed only minimum reduction in infectivity up to 49 hours post inoculation. The stability of virus in tissue culture medium was shown to be directly related to pH 6.0-8.0, being more stable at the acid pH values. The degree of cytopathogenicity induced in chick kidney cells following infection with IBV was directly related to the pH at which the cells were incubated, occurring earlier and more extensively in cells at the higher pH values. Cell macromolecule synthesis in chick kidney cells was inhibited following infection with IBV and was apparently due to cell damage and death.

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Mentioned in this Paper

Cell Injury
Infectious bronchitis virus
Cytopathogenic Effect, Viral
Virus Replication
Protein Biosynthesis
Culture Techniques
Cell Fusion Procedure
Macromolecule Biosynthetic Process

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