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Effect of pharmacological agents on human keratinocyte mitosis in vitro. II. Inhibition by catecholamines

Journal of Cellular Physiology

Oct 1, 1975

Richart Harper, B Allen Flaxman

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Abstract

Catecholamines produce mitotic inhibition in primary cell cultures of human keratinocytes probably via a block in the G2 part of the cell cycle. Epinephrine produced significant mitotic inhibition (49%) at a concentration as low as 4.5 X 10(-10) M, while its analog, isoproterenol, produ...read more

Mentioned in this Paper

Small Molecule
Beta Adrenoceptor Activity
Analogs & derivatives
Obstruction
Z-Max
Propranolol
Receptors, Adrenergic, beta-1
Norepinephrine
Dose-Response Relationship, Drug
Norepinephrine, (+, -)-Isomer
Paper Details
References
    • References10
    • Citations12
    • References10
    • Citations12
  • Effect of pharmacological agents on human keratinocyte mitosis in vitro. II. Inhibition by catecholamines

    Journal of Cellular Physiology

    Oct 1, 1975

    Richart Harper, B Allen Flaxman

    PMID: 410

    DOI: 10.1002/jcp.1040860213

    Abstract

    Catecholamines produce mitotic inhibition in primary cell cultures of human keratinocytes probably via a block in the G2 part of the cell cycle. Epinephrine produced significant mitotic inhibition (49%) at a concentration as low as 4.5 X 10(-10) M, while its analog, isoproterenol, produ...read more

    Mentioned in this Paper

    Small Molecule
    Beta Adrenoceptor Activity
    Analogs & derivatives
    Obstruction
    Z-Max

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    Paper Details
    References
    • References10
    • Citations12
    • References10
    • Citations12
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