Effect of pharmacological doses of 3-0-methyl-D-glucose and 2-deoxy-D-glucose on rat brain glucose and lactate

Stroke; a Journal of Cerebral Circulation
L P MillerW H Oldendorf

Abstract

The present investigation examined the effects of two glucose analogues, 3-0-methyl-D-glucose (30MG) and 2-deoxy-D-glucose (2DOG) on basal levels of rat brain glucose and lactate. The results showed that pretreatment (iv) with 30MG up to 2 g/kg caused a transient drop in brain glucose levels to 42% of control value within 2.5 min and a drop in lactate levels to 75% of control value by 5 min. 2DOG administration (2 g/kg) affected glucose in a biphasic response with an initial drop to 46% of control value seen by 2.5 min, followed by a progressive increase to 290% of the control value by 40 min. This elevated level of glucose was sustained for approximately 40 min. Lactate levels responded to 2DOG administration by a decrease to 37% of control value within 10 min post-injection and returned to near basal levels by 160 min. A dose response was also examined for both compounds. Behaviorally 30MG had no apparent effects. However, the response to 2DOG was a reduction in voluntary movements, piloerection, irregular clonic jerks, splayed limbs and fits of wild running. These experiments were designed to evaluate the potential of 30MG or 2DOG for attenuating the well documented rise in brain lactate levels following an ischemic insult. ...Continue Reading

References

May 1, 1979·Stroke; a Journal of Cerebral Circulation·W A Pulsinelli, J B Brierley
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C NicholsonH Stöckle
Jul 27, 1979·Biochimica Et Biophysica Acta·J Marion, L S Wolfe
Jan 1, 1976·Advances in Experimental Medicine and Biology·N G Bazán
Jan 1, 1977·Stroke; a Journal of Cerebral Circulation·K A HossmannV Zimmerman
Sep 1, 1973·Journal of Neurochemistry·R W HortonH S Bachelard
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö
May 1, 1983·Journal of Neurochemistry·W A Pulsinelli, T E Duffy
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R J HarrisM Bayhan
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S RehncronaB K Siesjö

❮ Previous
Next ❯

Citations

Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David M CohenLouis Sokoloff
Dec 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·O P AshirovaO S Medvedev
Feb 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·O S MedvedevA N Murashev
Nov 1, 1988·Brain Research Bulletin·L R DrewesD Z Gerhart
Sep 23, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michal RivlinGil Navon
May 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tao JinSeong-Gi Kim
May 13, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michal Rivlin, Gil Navon
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W G Kuhr, J Korf
Sep 13, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Akansha Ashvani SehgalPeter C M van Zijl
Jan 1, 1991·The British Journal of Ophthalmology·P N BishopR W Stoddart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.