Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse

Biochemical Pharmacology
H ZaherF J Gonzalez

Abstract

Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily by both transcriptional and post-transcriptional mechanisms. Using the Ahr -/- mice, we examined the induction of CYP1A1 and CYP1A2 by PB. CYP1A2 mRNA and protein were induced by PB in the null mice, suggesting that CYP1A2 is regulated by PB by a mechanism independent of the aryl hydrocarbon receptor (AHR). In contrast, the regulation of CYP1A1 is highly dependent on the AHR.

References

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Citations

Mar 30, 2004·Biochemical and Biophysical Research Communications·Steven RoblinPatricia A Harper
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y ShimizuT Ishikawa
Jan 15, 2011·Cardiovascular Research·Maria VolkovaRaymond R Russell
Feb 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephanie P Jones, Sean W Kennedy
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Jul 27, 2000·Carcinogenesis·Q A Khan, A Dipple
Jan 31, 2012·Journal of Biochemical and Molecular Toxicology·Marumi OhnoMayumi Ishizuka
Jul 24, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Masutaka FurueGaku Tsuji
Apr 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eija PeltonenSatu Alaluusua
May 23, 2012·Journal of Applied Toxicology : JAT·Waranya ChatuphonprasertKanokwan Jarukamjorn
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Aug 6, 2004·Toxicology Letters·Bowhan JinDoug-Young Ryu
Aug 24, 2010·Advanced Drug Delivery Reviews·Antonia H Tolson, Hongbing Wang

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