PMID: 1234506Jun 1, 1975

Effect of phenobarbitone on hepatic drug-metabolizing enzymes and urinary D-glucaric acid excretion in man

British Journal of Clinical Pharmacology
D S LecamwasamP Turner

Abstract

1 The activities of some hepatic drug-metabolizing enzymes representative of the four major pathways for the biotransformation of drugs were estimated in diagnostic wedge biopsy specimens obtained from 22 patients with Hodgkin's disease. Twelve patients (nine males and three females) were not on prolonged pre-operative treatment with any known inducing drugs. In this group, hexobarbitone oxidase activity, cytochrome P450 and microsomal protein contents were in the same range as those reported by other workers. 2 Ten patients (five males and five females) were pre-operatively treated with phenobarbitone (90 mg daily) for at least seven days. This resulted in a significant increase of hexobarbitone oxidase activity, cytochrome P450 and microsomal protein contents when the phenobarbitone untreated and treated groups were compared as a whole and provides direct evidence of induction of hepatic mixed function oxidase system. In respect of p-nitroreductase, 1-leucyl-beta-naphthylamide splitting enzyme and UDP glucuronyl transferase, there was no difference between the treated and untreated groups. 3 When untreated and treated patients were compared, the induction of the hepatic mixed function oxidase system, was associated with a sig...Continue Reading

References

May 25, 1974·Lancet·G W Hepner
Mar 1, 1972·European Journal of Clinical Pharmacology·B SchoeneH F von Oldershausen
Sep 1, 1973·Clinical Pharmacology and Therapeutics·O PelkonenN T Kärki
Apr 1, 1974·The Journal of Pharmacy and Pharmacology·A N Latham
Aug 23, 1974·European Journal of Clinical Pharmacology·J L Cunningham, D A Evans
Nov 30, 1974·British Medical Journal·J A ForrestI H Stevenson
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Citations

Jul 12, 2008·Archives of Toxicology·Olavi PelkonenHannu Raunio
Jan 1, 1988·Pharmacology & Therapeutics·P Beaune, F P Guengerich
Jan 1, 1990·Pharmacology & Therapeutics·M Barry, J Feely
Aug 17, 2002·Alimentary Pharmacology & Therapeutics·L E Schmidt, K Dalhoff
Dec 1, 1975·British Journal of Clinical Pharmacology·D S Lecamwasam
Sep 1, 1995·Clinical Pharmacology and Therapeutics·P ReidenbergM Guillaume
Sep 24, 2005·Fundamental & Clinical Pharmacology·M Strolin BenedettiE Baltes
Apr 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B G LakeA Rundle
Nov 6, 2012·Expert Review of Clinical Pharmacology·Janne Hukkanen
Apr 1, 1980·European Journal of Clinical Pharmacology·E SotaniemiM Puukka
Sep 9, 1976·Drug Intelligence & Clinical Pharmacy·S R Brown, E A Hartshorn
Jan 1, 1978·Annals of Clinical Biochemistry·W J Marshall
Oct 29, 2020·Archives of Toxicology·Jukka HakkolaOlavi Pelkonen

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