Effect of phenprocoumon on monitoring of lepirudin, argatroban, melagatran and unfractionated heparin with the PiCT method

Pathophysiology of Haemostasis and Thrombosis
Tivadar FenyvesiJ Harenberg

Abstract

Prothrombinase-induced clotting time (PiCT) is a clotting-time test for heparins and direct thrombin inhibitors to reduce drawbacks of aPTT. Effects of the direct thrombin inhibitors lepirudin, argatroban, melagatran and of unfractionated heparin (UFH) were investigated in normal and oral anticoagulant plasma samples. Lepirudin showed potentiating interferences with phenprocoumon effects. Melagatran, argatroban and UFH delivered distinct linear additive effects in both plasma sample groups. PiCT ratio reduces differences between both groups with UFH, and argatroban inhibitor-receptor-binding mode plays a role in interaction patterns.

Citations

Sep 1, 2005·Journal of Thrombosis and Thrombolysis·Tivadar FenyvesiIngrid Jörg
Apr 15, 2004·American Journal of Clinical Pathology·Robert C GosselinJohn T Owings
Feb 26, 2010·Thrombosis Research·Birgitta SalmelaRiitta Lassila
Jul 1, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jeanine M WalengaHans-Klaus Breddin
Aug 18, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Marta A Miyares, Kyle Davis
Sep 25, 2004·Archives of Pathology & Laboratory Medicine·Robert C GosselinJohn T Owings

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