PMID: 8589058Jan 1, 1995Paper

Effect of phenylarsine oxide on the fission yeast Schizosaccharomyces pombe cell cycle

Biochimie
M L OustrinB Ducommun

Abstract

Phosphotyrosyl turnover is an essential regulatory mechanism for many biological processes, and the balance between tyrosine kinases and phosphatases plays a major role in the control of cell proliferation. Phenylarsine oxide (PAO), a potent inhibitor of tyrosine phosphatases (PTPase), was used to investigate the involvement of PTPase in the growth and control of the cell cycle of the fission yeast Schizosaccharomyces pombe. Cell proliferation was arrested by treatment with PAO, which was found to inhibit cdc25 PTPase in vitro but appeared not to act in vivo on this mitosis inducer. The PAO-treated cells displayed a mono- or binucleated phenotype and a DNA content that was either 2C or 4C, indicating a cell cycle arrest with a failure to complete cytokinesis. Entry into the cell division cycle from the G0 quiescent stage was also delayed by treatment with PAO. These results suggest that a number of key events in the mitotic cell cycle are regulated by as yet unidentified PTPases.

References

Oct 30, 1992·Biochemical and Biophysical Research Communications·D Hecht, Y Zick
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E CoolR L Margolis
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P Garcia-MoralesL E Samelson
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S OttilieR L Erikson
Feb 28, 1990·Biochemical and Biophysical Research Communications·B DucommunD Beach
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M BernierM D Lane

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Citations

Mar 20, 2010·The Journal of Biological Chemistry·Jian-Qiang ChenHong Lu
Feb 19, 2008·Developmental Biology·J Fernando Covian-NaresSteven S Vogel
Jan 22, 2020·Metallomics : Integrated Biometal Science·Shahbaz Ahmad ZakkiHidekuni Inadera

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