PMID: 6409671Aug 8, 1983Paper

Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon

FEBS Letters
F Assimacopoulos-JeannetB Jeanrenaud

Abstract

In isolated rat hepatocytes phenylephrine promotes a rapid increase in the amount of pyruvate dehydrogenase present in its active form (PDHa). This action is mediated by alpha 1-adrenergic receptors and is not observed in Ca2+-depleted hepatocytes. It is mimicked by the Ca2+ ionophore A23187. No changes in metabolites known to affect PDH activity are measured 3 min after addition of phenylephrine. Glucagon also increases PDHa, its action is additive to that of phenylephrine. The action of phenylephrine on PDHa could be explained by an increase in mitochondrial free Ca2+.

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Citations

Dec 1, 1991·Journal of Bioenergetics and Biomembranes·R G Hansford
Jan 1, 1991·The International Journal of Biochemistry·R Moreno-Sánchez, M E Torres-Márquez
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Nov 26, 2009·Experimental Biology and Medicine·Pratip BhattacharyaRolf Bünger
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Nov 1, 1990·The American Journal of Physiology·T W Moon, T P Mommsen
Jun 1, 1985·The American Journal of Physiology·J H Exton
Dec 1, 1985·The American Journal of Physiology·R M Denton, J G McCormack

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