PMID: 2508745Oct 17, 1989Paper

Effect of phosphatidylethanolamine and its constituent base on the metabolism of linoleic acid in rat liver

Biochimica Et Biophysica Acta
K ImaizumiM Sugano

Abstract

Dietary phosphatidylethanolamine (PE) contributes the circulatory and hepatic free-ethanolamine in rats (Ikeda et al. (1987) Biochim. Biophys. Acta 921, 245). A role for circulatory ethanolamine has not been defined; however, our recent studies have shown that exogenous ethanolamine influences cholesterol and linoleic acid metabolism in rats (Imaizumi et al. (1983) J. Nutr. 113, 2403). In order to understand the role of dietary PE the effects of PE and its base on the hepatic metabolism of linoleic acid were investigated in vivo and in primary cultured hepatocytes in rats. Dietary PE increased the plasmic level of ethanolamine from 37 to 52 microM and decreased the ratio of arachidonate to linoleate in hepatic phospholipids. Activity of hepatic delta 6-desaturase decreased in rats given PE and the desaturation of [14C]linoleate in the cultured hepatocytes decreased by the addition of ethanolamine. Secretion [14C]linoleate labeled very-low-density lipoprotein from the cultured hepatocytes decreased by the addition of ethanolamine. Dietary PE caused an increased formation of CO2 from [14C]acetate by liver slices, and ethanolamine added to the hepatocytes caused an increased oxidation of [14C]linoleate and a suppression of fatty a...Continue Reading

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Nov 23, 2011·Journal of Nanoscience and Nanotechnology·Chan-Yang LeeSang-Kwon Lee

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Citations

Jul 5, 2003·Bioscience, Biotechnology, and Biochemistry·Yasuhiko ShimadaKimio Sugiyama
Jun 6, 2003·Bioscience, Biotechnology, and Biochemistry·Yasuhiko ShimadaKimio Sugiyama
Apr 19, 2006·In Vitro Cellular & Developmental Biology. Animal·Hisae Kume, Hajime Sasaki
Jan 8, 2008·Progress in Lipid Research·Koji Nagao, Teruyoshi Yanagita
Feb 1, 1994·Scandinavian Journal of Gastroenterology·L AnderssonA Nilsson
Jan 3, 1992·Biochimica Et Biophysica Acta·K ImaizumiM Sugano

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