PMID: 9437660Jan 23, 1998Paper

Effect of phosphomonoesters, phosphodiesters, and phosphocreatine on glutamate uptake by synaptic vesicles

Molecular and Chemical Neuropathology
C J XuJ W Pettegrew

Abstract

L-Glutamate, a major excitatory amino acid, plays an important role in learning and memory. L-Glutamate uptake into synaptic vesicles is an ATP-dependent process. Exposure of neurons to high, sustained extracellular concentrations of glutamate results in excitotoxicity. Elevated levels of phosphomonoesters (PMEs), phosphodiesters (PDEs), and phosphocreatine (PCr) have been reported in Alzheimer disease (AD). In this article, the effects of selected PMEs, PDEs, and PCr on vesicular L-[3H]glutamate uptake into isolated bovine synaptic vesicles are investigated. D-myo-Inositol-1-monophosphate (I1P), D-myo-inositol-2-monophosphate (I2P), sn-glycero-3-phosphate, (alpha-GP) and PCr significantly stimulated L-[3H]glutamate uptake into synaptic vesicles. Phosphoethanolamine (PE), phosphocholine (PC), L-phosphoserine (L-PS) sn-glycero-3-phosphocholine (GPC), and sn-glycero-3-phosphoethanolamine (GPE) had little or no effect on vesicular L-glutamate uptake. These observations suggested that the vesicular uptake of glutamate can be regulated by endogenous PMEs and PCr. The mechanism of activation by I1P, I2P, and alpha-GP appears to be stimulation of Mg(2+)-ATPase activity. These effects on vesicular glutamate uptake may be important in d...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R M NitschR J Wurtman
Jan 1, 1992·Annual Review of Biochemistry·P W Majerus
May 28, 1992·The New England Journal of Medicine·J D RothsteinR W Kuncl
Jan 20, 1992·Neuroscience Letters·E M FykseF Fonnum
Jul 1, 1991·Pharmacology & Toxicology·M R Hirvonen
May 1, 1990·Journal of Neurochemistry·A T LoburT Ueda
Oct 1, 1986·Archives of Neurology·J T Greenamyre
Jan 1, 1989·Methods in Enzymology·P E Kish, T Ueda
Jan 1, 1985·Journal of Neurochemistry·S Naito, T Ueda
May 1, 1988·Journal of Neuropathology and Experimental Neurology·J W PettegrewK Panchalingam
Jun 19, 1986·Nature·D G Nicholls, T S Sihra
Apr 1, 1993·Neurochemical Research·K Hirose, P H Chan
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Jan 1, 1994·Neurobiology of Aging·J W PettegrewL R Muenz
Jan 1, 1993·Neurobiology of Aging·C D SmithW R Markesbery
May 1, 1996·Neurobiology of Aging·W E KlunkJ W Pettegrew

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