PMID: 58987May 1, 1976

Effect of phthalate plasticizer on blood compatibility of polyvinyl chloride

Journal of Pharmaceutical Sciences
S W KimE S Lee

Abstract

The amount of a phthalate plasticizer on the surface of a sheet of polyvinyl chloride used in the fabrication of blood storage bags was quantified using attenuated total reflectance spectroscopy, water contact angle measurement, and weight loss due to methanol extraction. Water wettability increased as the amount of surface phthalate extracted by methanol increased, which indicates that the accumulation of phthalate on the surface increases hydrophobicity. The extraction of phthalate by methanol consists of two steps: (a) methanol first dissolves surface phthalate, and (b) phthalate in the bulk then diffuses through the surface. The adsorption of plasma proteins was investigated to determine the initial events as blood contacts the surface. The composition of adsorbed proteins on the methanol-cleansed surface differs from that on the uncleansed polyvinyl chloride surface. Albumin adsorption onto phthalate-contaminated surfaces is less than on cleansed surfaces while adsorption of gamma-globulin and fibrinogen is greater on phthalate-contaminated surfaces. Protein adsorption can be related to surface thrombus formation. Increases in platelet numbers appeared on phthalate-contaminated surfaces as compared with methanol-treated su...Continue Reading

References

Mar 1, 1974·Thrombosis Research·R G LeeS W Kim
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Citations

Oct 1, 1979·Bulletin of Environmental Contamination and Toxicology·F P BellE E Nishizawa
Apr 16, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Alexey KondyurinMarcela M M Bilek
Aug 1, 1995·Artificial Organs·J M CourtneyG D Lowe
Jan 1, 1978·Clinical Toxicology·W H Lawrence
Apr 28, 2011·Journal of Pharmaceutical Sciences·Jared S BeeMariana N Dimitrova
Jul 1, 1978·Toxicology and Applied Pharmacology·J A ThomasL Martis
Dec 3, 2014·General and Comparative Endocrinology·Justine Mathieu-DenoncourtValerie S Langlois
Feb 1, 1984·Analytical Chemistry·P W AlbroJ L Schroeder
Jan 1, 1983·Journal of Biomedical Materials Research·P M Triolo, J D Andrade
Jan 1, 1984·Critical Reviews in Toxicology·J A Thomas, M J Thomas

Related Concepts

Adsorption
Serum Proteins
Bos indicus
Gamma globulin
Phthalic Acids
Platelet Adhesiveness
Vinylite
Polyvinyls
Plasma Protein Binding Capacity
Dall Sheep

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