Effect of physical activity and fasting on gut and liver proteolysis in the dog

The American Journal of Physiology
A E HalsethD H Wasserman

Abstract

The aim of this study was to determine how gut and liver protein kinetics adapt to acute exercise in the 18-h-fasted dog (n = 7) and in dogs glycogen depleted by a 42-h fast (n = 8). For this purpose, sampling (artery and portal and hepatic veins) and infusion (vena cava) catheters and Doppler flow probes (portal vein and hepatic artery) were implanted with animals under general anesthesia. At least 16 days later, an experiment, consisting of a 120-min equilibration period, a 30-min basal sampling period, and a 150-min exercise period, was performed. At the start of the equilibration period, a constant rate infusion of [1-13C]leucine was initiated. Gut and liver leucine appearance and disappearance rates were calculated in these studies by combining a novel stable isotopic method and arteriovenous difference methods. In the determination of tissue leucine kinetics the tissue inflow of both alpha-[13C]ketoisocaproic acid and [13C]leucine was taken into account. The results of this study show that 1) the splanchnic bed (liver plus gut) contributes approximately 40% to the whole body proteolytic rate in the basal state and during exercise in dogs fasted for either 18 or 42 h, 2) the contributions of the gut and liver to splanchnic...Continue Reading

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Citations

Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·P RittlerW H Hartl
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D G BurrinP T Sangild
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Jean-Christophe J BouthegourdPatrick C Even
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·D K LevenhagenP J Flakoll
May 13, 2003·Journal of Applied Physiology·R Richard PencekDavid H Wasserman
Oct 19, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Mohsen T SaberiSue E Samuels

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