Effect of physical fitness and endurance exercise on indirect biomarkers of recombinant growth hormone misuse: insulin-like growth factor I and procollagen type III peptide

International Journal of Sports Medicine
Rosario AbellanJordi Segura

Abstract

Serum insulin-like growth factor-I (IGF-I) and procollagen type III peptide (P-III-P) have been proposed as indirect biomarkers of rhGH misuse in sports. The purpose of the present study was to investigate concentrations of these biomarkers in athletes at different levels of physical fitness and endurance exercise. Serum total IGF-I and P-III-P were measured in 96 elite athletes of various sports along the training season; in 21 recreational athletes at baseline non-exercising conditions and in another 129 recreational athletes before and after long-distance races (10 and 21 km). No differences were evidenced for IGF-I concentrations, but statistically higher values of serum P-III-P were found in elite athletes compared to recreational ones. Among elite athletes, the specific sport did not affect serum IGF-I. However, P-III-P was statistically higher in the sport performed by the youngest athletes (rhythmic gymnastics), even after correction of the logarithm of the concentration by the reciprocal of age. Over the training season, the within-athlete variabilities of IGF-I and P-III-P in elite athletes were low (22.8 % and 21.7 %, respectively). Recreational athletes taking part in a 21 km competition race showed a significant in...Continue Reading

Citations

Oct 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Martin Bidlingmaier, Christian J Strasburger
Jul 20, 2010·Annual Review of Analytical Chemistry·Larry D Bowers
Aug 1, 2009·Bioanalysis·Chunji He, Moutian Wu
Jul 5, 2011·Physiology & Behavior·Éadaoin W GriffinAine M Kelly
Jun 2, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Osquel BarrosoOlivier Rabin
Jan 22, 2009·Therapeutic Drug Monitoring·Jordi SeguraSimona Pichini

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