PMID: 592708Nov 1, 1977

Effect of physical loads on lipid and carbohydrate metabolic indices in hypokinesis

Kosmicheskaia biologiia i aviakosmicheskaia meditsina
T M Lobova, A V Chernyĭ


Experiments on 140 white rats kept under hypokinetic conditions for 15, 30, 60 and 90 days showed a significant decrease of the glycogen content in the liver and skeletal muscles, acceleration of lipolysis in the adipose tissue, progressive increase of the content of nonesterified fatty acids, ketone bodies and cholesterol in the blood, decrease of the content of total lipids and increase of the cholesterol content in the skeletal muscles and liver. Hypokinetic rats exposed to exercises (swimming) also exhibited changes in carbohydrate and lipid metabolism; however the content of ketone bodies in the blood increased a little, the glycogen content in tissues decreased to a lesser extent, the cholesterol level in the and skeletal muscles increased only on the 15th day, remained at the control level at later stages and even decreased in the skeletal muscles. Thus, during an exposure to hypokinesia and its combination with exercises the role of lipids on the energy balance of the animal body increases. Exercises facilitate better utilization of lipids, thus delaying adverse effects of hypokinesia.

Related Concepts

Fat Pad
Nonesterified Fatty Acids
Ketone Bodies
Liver Glycogen
Physical Restraint

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.