Effect of physical restraint on oxidative stress in mice fed a selenium and vitamin E deficient diet

Biological Trace Element Research
P K SouthO A Levander

Abstract

Physical restraint has been associated with increased oxidative damage to lipid, protein, and DNA. The purpose of this experiment was to determine whether physical restraint would further exacerbate oxidative stress in mice fed a selenium (Se) and vitamin E (VE) deficient diet. Three-week- old mice were fed a Torula yeast diet containing adequate or deficient Se and VE. Menhaden oil was added to the deficient diet to impose an additional oxidative stress. After 4 wk feeding, half the mice in each group were restrained for 5 d in well-ventilated conical tubes for 8 h daily. Mice fed the Se and VE deficient diets had increased liver thiobarbituric acid-reactive substance (TBARS) levels and decreased liver glutathione peroxidase (GPX1) activity and alpha-tocopherol levels. Plasma corticosterone levels were elevated in restrained mice fed the deficient diet compared to unrestrained mice fed the adequate diet. Restraint had no effect on liver TBARS or alpha-tocopherol levels. Liver GPX1 activity, however, was lower in restrained mice fed the adequate diet. In addition, liver superoxide dismutase (SOD) activity was lower in the restrained mice fed the adequate or deficient diet. Thus, under our conditions, Se and VE deficient diet, b...Continue Reading

Citations

Jan 13, 2011·Biological Trace Element Research·Fatma Arik ColakogluSerhat Colakoglu
Sep 21, 2006·Molecular Neurodegeneration·Melinda M PetersEdwin J Weeber
Oct 8, 2011·Bioscience, Biotechnology, and Biochemistry·Yuki TeradaAsako Takenaka
May 12, 2007·Toxicology·Victoria LinaresJosé L Domingo

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