Effect of physical training on the age-related changes of acetylcholinesterase-positive fibers in the hippocampal formation and parietal cortex in the C57BL/6J mouse

Mechanisms of Ageing and Development
Y C ChenS L Wang

Abstract

We investigated the effect of a moderate amount of prolonged physical training initiated at 3 months of age on the age-related changes of the hippocampal and cortical cholinergic fibers. A total of 80 male C57BL/6J mice were divided into five groups which were trained (including adult and old trained, AT and OT), sedentary (adult and old sedentary, AS and OS) and young (Y). From 3 months old, the mice of the trained groups were treated with a voluntary running wheel for 1 h each day, 5 days per week. AT had been trained up to 13-month-old whereas OT up to 24 months old. At the same time, the mice of the sedentary groups were put in immobilized wheels. We set the criterion for effective training in the trained mice such that the heart-to-body weight ratio should be at least 2 S.D. above the mean in the age-matched groups. Using AChE histochemistry and stereology, the AChE-positive fibers were analyzed quantitatively in the molecular layers in CA1, CA3 and the dentate gyrus of the hippocampal formation, and in III, V layers in the motor and somatosensory cortex. Comparison of Y, AS and OS (3, 13 and 24 months of age) showed minimum AChE-positive fiber density in the hippocampal formation and the cortex in OS (P < 0.01). After 10 ...Continue Reading

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Citations

Apr 26, 2003·Neurobiology of Aging·Allen W BrownBörje Bjelke
Mar 25, 2015·NeuroImage·Lindsay S CahillJohn G Sled
May 18, 2007·Neurobiology of Aging·Athéna Rebecca YpsilantiIsabelle Aubert
May 1, 2009·Journal of Neuroscience Research·Wei ZhangYong Tang
May 2, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Wei LuYong Tang
Apr 2, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Sanrong WangYong Tang
Mar 7, 2019·The Journal of Pharmacology and Experimental Therapeutics·Fa-Ju ChenJing-Shan Shi
Jun 6, 2018·Frontiers in Aging Neuroscience·Patrizia FattorettiCarlo Zancanaro

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