PMID: 6601928Mar 1, 1983

Effect of physiological manipulations on the chemotherapy of experimentally induced renal infection

Antimicrobial Agents and Chemotherapy
T Miller, S Phillips

Abstract

The belief that a favorable physiological milieu in the urinary tract may augment the effectiveness of antimicrobial agents used to treat urinary tract infections was examined by using an experimental model of Escherichia coli-induced renal infection in rats. The effect of manipulating urinary pH and flow on the antimicrobial activities of gentamicin, carbenicillin, ampicillin, nitrofurantoin and co-trimoxazole was assessed. In addition, a potential synergistic effect of the sequential administration of gentamicin and cephalothin in the eradication of renal infection was investigated. Although significant physiological alterations were achieved, these did not affect the efficacy of the antimicrobial agents studied, and therapeutic failures were common.

References

Feb 1, 1976·Archives of Internal Medicine·A WheltonW G Walker
Aug 1, 1976·Antimicrobial Agents and Chemotherapy·P J ChiuJ F Long
Jun 1, 1975·Kidney International·T MillerS Burnham
Dec 10, 1966·Lancet·P J Little, H E De Wardener
Mar 1, 1973·The Journal of Infectious Diseases·T Miller, K B Robinson
Sep 1, 1974·Kidney International·A Whelton, W G Walker
May 1, 1973·Annals of Internal Medicine·A WheltonW G Walker
Sep 27, 1967·Annals of the New York Academy of Sciences·W Brumfitt, A Percival
Jan 1, 1982·Kidney International·V L Thomas, M Forland
Sep 1, 1980·The Journal of Clinical Investigation·M A Horwitz, S C Silverstein

Related Concepts

Ukapen
Antiseptics, Urinary
Pyopen
Diuresis
Drug Combinations
Gentacycol
Hydrogen-Ion Concentration
Kidney
Kidney Diseases
Nitrofurantoin Sodium Salt

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