PMID: 2506606Jan 1, 1989Paper

Effect of physostigmine on memory consolidation and retrieval processes in intact and nucleus basalis-lesioned rats

Psychopharmacology
A C SantucciV Haroutunian

Abstract

The efficacy of physostigmine on memory enhancement in rats trained on a passive avoidance task was investigated. In experiment 1, the effect of posttraining injections of physostigmine (0.03 mg/kg) in subjects tested at either short (1.25 h or 72 h) or long (3 weeks or 5 weeks) retention intervals was explored. Results indicated drug-induced enhancement of memory at only the two short intervals. Experiment 2 examined the mnemonic consequences of pretest administration of physostigmine. Administration of physostigmine (0.015 mg/kg and 0.03 mg/kg) shortly prior to testing led to a significant potentiation of memory retrieval. The aim of experiment 3 was to determine whether or not an intact cholinergic system is necessary for pretest physostigmine to enhance memory retrieval. Results from this experiment indicated that physostigmine (0.03 mg/kg) was effective in enhancing memory in rats prepared with ibotenic acid-induced lesions of the nucleus basalis of Meynert. Together, these data provide further empirical support for the importance of the cholinergic system in memory processes.

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Citations

Jan 1, 1992·Psychopharmacology·D K Rush, K Streit
Jun 1, 1995·Psychopharmacology·W J JacksonD K Rush
Jan 1, 1990·Physiology & Behavior·V HaroutunianP D Kanof
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Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Anthony C Santucci, Vahram Haroutunian
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