Effect of phytoestrogens on sexual function in menopausal women: a systematic review and meta-analysis

Climacteric : the Journal of the International Menopause Society
M Najaf Najafi, Masumeh Ghazanfarpour

Abstract

This systematic review and meta-analysis aimed to critically evaluate the effectiveness of phytoestrogens on sexual disorders and severity of dyspareunia. Relevant studies were identified through a systematic search of major databases such as PubMed, Cochrane Library, ISI Web of Science, and Scopus up to 29 September 2017, without any time limit. Two independent reviewers screened all abstracts and full-text articles. The final version of Jadad scale was used for evaluating the quality of trials. Soy did not have an effect on sexual function (standardized mean difference [SMD] = 1.099 [95% CI: -3.033 to 0.835, p = 0.265]; heterogeneity I2 = 80%; p = 0.006; random-effect model; three trials) but improved dyspareunia (p > 0.05). Red clover showed no significant effect on sexual function (SMD = -0.087 [95% CI: -0.936 to 0.763, p = 0.842]; heterogeneity I2 = 0%, p = 0.397; fixed-effect model; two trials) and sexual satisfaction (p > 0.05). Phytoestrogens isolated from Lepidium meyenii, Foeniculum vulgare, and maritime pine bark as well as Trigonella foenum-graecum L. significantly improved sexual function. In contrast, phytoestrogens isolated from Korean red ginseng and flaxseed did not lead to significant effect on sexual function...Continue Reading

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Citations

Aug 12, 2020·Phytotherapy Research : PTR·Jéssica C P Petrine, Bruno Del Bianco-Borges
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Amanda Alves LoziReggiani Vilela Gonçalves
Mar 13, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Sousan HafiziMalihe Tabarrai
Aug 12, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Martha Villar-LópezEdward Mezones-Holguín
Aug 10, 2021·American Journal of Lifestyle Medicine·Rashmi KudesiaMichelle Tollefson

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