Effect of pioglitazone on carotid intima-media thickness and arterial stiffness in type 2 diabetic nephropathy patients

Metabolism: Clinical and Experimental
Tsukasa NakamuraH Koide

Abstract

Atherosclerosis is the major cause of morbidity and mortality in patients with type 2 diabetes, and pioglitazone has been reported to have anti-inflammatory and potential antiatherogenic effects. The aim of the present study was to determine whether pioglitazone, glibenclamide, or voglibose affects carotid intima-media thickness (IMT), pulse wave velocity (PWV), and urinary albumin excretion (UAE) in normotensive type 2 diabetic nephropathy patients. Forty-five normotensive type 2 diabetes patients with microalbuminuria were randomized to 12-month treatment with pioglitazone (30 mg/d, n = 15), glibenclamide (5 mg/d, n = 15), or voglibose (0.6 mg/d, n = 15). Pre- and posttreatment UAE, PWV, and IMT values were compared between treatment groups and a group of age-matched healthy control subjects (n = 30). Pretreatment PWV, IMT, and UAE values differed little between the 3 groups, but UAE was greater in the 45 type 2 diabetes patients (132.5 +/- 36.4 microg/min) than in the control subjects (6.2 +/- 1.8 microg/min, P < .001). IMT (0.76 +/- 0.12 mm) was significantly greater in the diabetics than in the controls (0.60 +/- 0.08 mm, P < .01). PWV (1,840 +/- 320 cm/s) was also significantly greater in the diabetics than in the control...Continue Reading

References

Dec 15, 2000·Journal of Human Hypertension·R PedrinelliM Mariani
May 7, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·F YoussefG Hamilton
May 25, 2002·Kidney International·Tetsuo ShojiYoshiki Nishizawa
Jul 3, 2002·Drugs·Fabrice M A C MartensTon J Rabelink
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira YamashinaYoshio Yamamoto
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Atsuhiro IchiharaTakao Saruta
Jun 7, 2003·Drug News & Perspectives·Doris M ThamJohn C Rutledge
Aug 13, 2003·Archives of Internal Medicine·Pernette R W de Sauvage NoltingJohn J P Kastelein

❮ Previous
Next ❯

Citations

Apr 26, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jochen WöhrleThorsten Nusser
Sep 22, 2007·Current Heart Failure Reports·J Cheriyan, Ian B Wilkinson
Aug 19, 2007·Journal of Cardiovascular Pharmacology·Eyal Leibovitz, Ernesto L Schiffrin
Jan 18, 2008·Nephrology·Cheuk-Chun Szeto, Philip Kam-Tao Li
Jun 26, 2007·Diabetes, Obesity & Metabolism·Jane E-B Reusch, Boris B Draznin
Mar 13, 2008·Diabetes, Obesity & Metabolism·R E Buckingham, A Hanna
May 29, 2008·Diabetes, Obesity & Metabolism·E MannucciN Marchionni
Apr 27, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuo EguchiKazuomi Kario
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tsukasa NakamuraKoichi Node
Mar 31, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Latika SibalPhilip D Home
Sep 10, 2011·Drugs·Pierre BoutouyrieAzra Mahmud
Dec 27, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Zoran HajdukovićSlavica Raden
Dec 4, 2009·QJM : Monthly Journal of the Association of Physicians·E Erdmann, R Wilcox
Aug 22, 2006·Expert Review of Cardiovascular Therapy·Andreas PfütznerThomas Forst
Mar 1, 2006·Expert Opinion on Pharmacotherapy·Andreas Pfützner, Thomas Forst
Jan 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Pantelis A SarafidisAnastasios N Lasaridis
Jun 9, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S Vigili de KreutzenbergA Avogaro
Jun 27, 2009·Clinics in Geriatric Medicine·Mary Ann Lim, Raymond R Townsend
May 29, 2009·International Journal of Cardiology·Satoru Sakuragi, Walter P Abhayaratna
May 19, 2009·Metabolism: Clinical and Experimental·Keiichiro HarashimaTooru Tsunoda
Sep 11, 2007·Journal of Diabetes and Its Complications·Aaron S Kelly, Alan J Bank
Jul 10, 2007·Metabolism: Clinical and Experimental·Jong Suk ParkHyun Chul Lee
Jan 16, 2007·European Journal of Internal Medicine·J W F Elte, J F Blicklé
Apr 22, 2008·Fundamental & Clinical Pharmacology·Pantelis A Sarafidis
Nov 10, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·M S YeeD G Johnston
Sep 16, 2010·Cardiovascular Therapeutics·Pantelis A SarafidisAnastasios N Lasaridis
Apr 19, 2013·Diabetes, Obesity & Metabolism·M MonamiE Mannucci
Jul 22, 2014·Journal of the American Geriatrics Society·Alfred K W WongJacqueline C T Close
May 14, 2009·The American Journal of Pathology·Hideaki NakayaJihong Han
Feb 14, 2006·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Abhijeet Goyal, Errol D Crook
Jul 15, 2006·Metabolism: Clinical and Experimental·Takahiro ArakiYoshiki Nishizawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.