Effect of pioglitazone on urinary liver-type fatty acid-binding protein concentrations in diabetes patients with microalbuminuria

Diabetes/metabolism Research and Reviews
Tsukasa NakamuraH Koide

Abstract

Urinary liver-type fatty acid-binding protein (L-FABP) is a useful marker for renal tubulointerstitial injury. Pioglitazone is reported to be effective in early diabetic nephropathy. The aim of the present study was to determine whether pioglitazone affects urinary L-FABP levels in diabetic nephropathy patients with microalbuminuria. Sixty-eight patients with type 2 diabetes and microalbuminuria were randomized to a 12-month treatment with pioglitazone (30 mg/d, n = 17), glibenclamide (5 mg/d, n = 18), voglibose (0.6 mg/d, n = 17), or nateglinide (270 mg/d, n = 16). Pre- and posttreatment urinary albumin excretion (UAE) and urinary L-FABP concentrations were compared between the four treatment groups and 40 age-matched healthy subjects. Pretreatment UAE and urinary L-FABP levels differed little between the four groups. UAE and urinary L-FABP levels were significantly greater in the diabetes patients than in the healthy subjects (UAE: p < 0.001; L-FABP: p < 0.01). After 6 and 12 months, UAE and urinary L-FABP were significantly lower in the pioglitazone treatment group than in the other treatment groups (UAE: 6 months, p < 0.01 and 12 months, p < 0.001; L-FABP: 6 months, p < 0.05 and 12 months, p < 0.01). Pioglitazone, but not g...Continue Reading

References

Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A HamiltonR G Reed
Mar 29, 2002·Kidney International·Robert Earl RouthKevin John McCarthy
May 23, 2003·Journal of the American Society of Nephrology : JASN·Carla ZojaGiuseppe Remuzzi
Jun 7, 2003·Drug News & Perspectives·Doris M ThamJohn C Rutledge
Nov 13, 2003·Current Diabetes Reports·Aled O Phillips
Jan 30, 2004·The Journal of Laboratory and Clinical Medicine·Atsuko KamijoMasao Omata
Aug 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M ShimabukuroS Ueda
Sep 18, 2004·Metabolism: Clinical and Experimental·Tsukasa NakamuraHikaru Koide
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Tsukasa NakamuraHikaru Koide
Oct 7, 2004·The American Journal of Pathology·Atsuko KamijoKenjiro Kimura
Nov 13, 2004·Metabolism: Clinical and Experimental·Mitsuo TanimotoYasuhiko Tomino
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·G SchernthanerUNKNOWN Quartet [corrected] Study Group
Jan 22, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K G ParhoferB Göke
Feb 4, 2005·Journal of the American Society of Nephrology : JASN·Stephen ZafiriouCarol A Pollock

❮ Previous
Next ❯

Citations

Mar 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge E ToblliNestor F Gonzalez-Cadavid
Sep 24, 2008·Expert Opinion on Investigational Drugs·Monica CortinovisGiuseppe Remuzzi
Apr 22, 2008·Expert Opinion on Pharmacotherapy·C V RizosM S Elisaf
Oct 16, 2008·Clinical and Experimental Hypertension : CHE·Tsukasa NakamuraKoichi Node
Jan 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Pantelis A SarafidisAnastasios N Lasaridis
Apr 19, 2013·Diabetes, Obesity & Metabolism·M MonamiE Mannucci
Jul 25, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Atsuko Kamijo-IkemoriKenjiro Kimura
Mar 7, 2009·The American Journal of Pathology·Tamami TanakaEisei Noiri
Feb 8, 2014·Ageing Research Reviews·Marijn M SpeeckaertJoris R Delanghe
Jun 4, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Atsuko Kamijo-IkemoriKenjiro Kimura
Jul 30, 2015·The Cochrane Database of Systematic Reviews·Bianca HemmingsenThomas P Almdal
Sep 25, 2018·The Cochrane Database of Systematic Reviews·Clement LoSophia Zoungas
Mar 30, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yi LiYucheng Yan

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