Effect of piperonyl butoxide on disposition of di-2-ethylhexyl phthalate by rainbow trout

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M J MelanconJ J Lech

Abstract

1. Piperonyl butoxide in vitro inhibits the oxidation and hydrolysis of di-2-ethylhexyl phthalate, and the hydrolysis of the butyl ester of 2,4-dichloro-phenoxyacetic acid by liver homogenate fractions and serum from rainbow trout. 2. The rates of oxidation and hydrolysis of di-2-ethylhexyl phthalate by liver homogenates from rainbow trout pre-exposed to piperonyl butoxide (1 mg/l) were considerably lower than those by liver homogenates from control trout. 3. Disposition of di-2-ethylhexyl [14C]phthalate in rainbow trout in vivo was modified by pre-exposure to piperonyl butoxide. The piperonyl butoxide-treated trout had lower levels of 14C in bile and higher levels of 14C in blood and muscle than control trout. 4. Muscle of control and piperonyl butoxide-exposed trout showed similar concentrations of mono-2-ethylhexyl phthalate but the concentration of di-2-ethylhexyl phthalate in muscle from piperonyl butoxide-exposed trout was three times the control value.

References

Jan 1, 1980·Archives of Environmental Contamination and Toxicology·P D GuineyR E Peterson
May 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M J Melancon, J J Lech
Jan 1, 1984·Drug Metabolism Reviews·R L BinderJ J Lech
Jun 1, 1981·Ecotoxicology and Environmental Safety·H W WoffordJ M Neff
Jan 1, 2006·Toxicology Mechanisms and Methods·David L Straus, Janice E Chambers

Related Concepts

Diethylhexyl Phthalate
Phenoxyacetic acid
Depression, Chemical
Phthalates
Phthalate
Oxidation
Salvelinus
Muscle
In Blood
Esters

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