Effect of piribedil, a D-2 dopaminergic agonist, on dopamine, amino acids, and free radicals in gerbil brain after cerebral ischemia

Molecular and Chemical Neuropathology
B DelbarreF Calinon

Abstract

The excitatory amino acids (EAA) are involved in the pathogenesis of the cerebral ischemia. Moreover, several investigators have demonstrated that a considerable amount of dopamine (DA) is released in the striatum after ischemia reperfusion/insult (IRI). Recently, studies have demonstrated in vitro, that D-2 agonist, at the level of striatum and retina, may represent a powerful signal to inhibit release of excitatory amino acids implicated in cerebral ischemia. Therefore we have been incited to test, in vivo, the action of a D-2 agonist, piribedil, on gerbil brain after IRI. We have used the Stroke Index (SI); then to precise the mechanism of action, we have determined the levels of dopamine, EAA, and hydroxyl-free radicals (OH), in striatum, hippocampus, and hemisphere. Piribedil, administered at dose of 10 mg/kg, per os, 60 min before induction of transient cerebral ischemia in gerbils, presents a neuroprotective effect, as measured by SI and significantly reverses the increase of DA, EAA, and OH induced by IRI. The mechanism of action of piribedil could be related to its D-2 agonist property.

References

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Citations

Feb 10, 1998·European Journal of Pharmacology·F CalziM T Tacconi
Jan 1, 1997·Clinical Therapeutics·H AllainS Belliard
May 10, 2000·Clinical Neuropharmacology·N J SolenskiG A Helm
Feb 12, 2013·Medical Hypotheses·Hiroto IshikawaCesar V Borlongan
Jul 31, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kevin A Strauss, D Holmes Morton
Jul 27, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A A Pilipovich, V L Golubev
Jul 13, 2006·Clinical and Experimental Hypertension : CHE·Paola CastriFrancesco Fornai

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